降钙素基因相关肽：强效血管舒张剂及降钙素基因的主要产物。
Calcitonin gene-related peptide: potent vasodilator and major product of calcitonin gene.
作者信息
Girgis S I, Macdonald D W, Stevenson J C, Bevis P J, Lynch C, Wimalawansa S J, Self C H, Morris H R, MacIntyre I
出版信息
Lancet. 1985 Jul 6;2(8445):14-6. doi: 10.1016/s0140-6736(85)90059-5.
PMID:2861456
Abstract
In addition to calcitonin and katacalcin, the human calcitonin gene encodes a novel peptide--calcitonin gene-related peptide (CGRP)--a potent vasodilator. A sensitive and specific radioimmunoassay was developed to study plasma levels of CGRP in normal subjects. CGRP circulates at five times the concentration of calcitonin, suggesting that it may be an important physiological regulator of vascular tone and blood flow.
摘要
除了降钙素和katacalcin外，人降钙素基因还编码一种新的肽——降钙素基因相关肽（CGRP），它是一种强效血管舒张剂。我们开发了一种灵敏且特异的放射免疫分析法来研究正常受试者血浆中CGRP的水平。CGRP的循环浓度是降钙素的五倍，这表明它可能是血管张力和血流的重要生理调节因子。
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