Department of Physiological Sciences, Warsaw, University of Life Sciences, Warsaw, Poland.
J Physiol Pharmacol. 2017 Apr;68(2):165-174.
Cancer is the second leading cause of death worldwide. Conventional cancer treatment like chemotherapy do not fulfil the expectations of both patients and physicians and there is a pressing need for a new kind of therapies that will increase drug delivery to the tumor mass. Standard chemotherapy does not show either specific tumor-targeting, or selective mode of action for cancer cells. Moreover, tumor microenvironments additionally disturb drug perfusion and diffusion. Currently approved anticancer drugs have many limitations and therefore special delivery systems improving their chemical and physical properties are beneficial. In the present review paper we discuss various drug delivery systems for solid tumors that are actually at various stages of pre-clinical tests or approved for therapy.
癌症是全球第二大死亡原因。像化疗这样的传统癌症治疗方法并没有达到患者和医生的期望，因此迫切需要一种新的治疗方法，以增加药物向肿瘤的输送。标准的化疗既没有显示出对肿瘤的特异性靶向，也没有显示出对癌细胞的选择性作用模式。此外，肿瘤微环境还会干扰药物的灌注和扩散。目前批准的抗癌药物有许多局限性，因此改善其化学和物理性质的特殊输送系统是有益的。在本综述论文中，我们讨论了各种用于实体瘤的药物输送系统，这些系统实际上处于临床前测试的不同阶段或已被批准用于治疗。
