氨苯蝶啶和阿米洛利对服用氢氯噻嗪的高血压患者尿沉渣的影响。
Effects of triamterene and amiloride on urinary sediment in hypertensive patients taking hydrochlorothiazide.
作者信息
Spence J D, Wong D G, Lindsay R M
出版信息
Lancet. 1985 Jul 13;2(8446):73-5. doi: 10.1016/s0140-6736(85)90180-1.
In a crossover study of 26 hypertensive patients, the effects of triamterene (50 mg/day) and amiloride (5 mg/day) on urinary sediment were compared. Each drug was given for one month and all patients also received hydrochlorothiazide (50 mg/day). An abnormal urinary sediment--evident grossly as a reddish-brown precipitate after routine staining procedures and microscopically as characteristic reddish-brown crystals and casts, as previously described--was identified in 14 of 26 (54%) triamterene urine samples but in none of the amiloride samples. Results of renal function tests were similar for both drugs. In a clinic population of more than 1000 hypertensive patients over 4 years, interstitial nephritis was diagnosed in 4, all of whom were taking a triamterene-containing combination diuretic. It is possible that triamterene is a factor in the aetiology of interstitial nephritis.
在一项针对26名高血压患者的交叉研究中，比较了氨苯蝶啶（50毫克/天）和阿米洛利（5毫克/天）对尿沉渣的影响。每种药物服用一个月，所有患者同时还服用氢氯噻嗪（50毫克/天）。在26份氨苯蝶啶尿液样本中，有14份（54%）出现异常尿沉渣——在常规染色程序后肉眼可见为红棕色沉淀，显微镜下可见为特征性的红棕色晶体和管型，如前所述——而在阿米洛利样本中均未出现。两种药物的肾功能测试结果相似。在4年多的时间里，对1000多名高血压患者的临床观察中，有4例被诊断为间质性肾炎，所有这些患者都在服用含氨苯蝶啶的复方利尿剂。氨苯蝶啶可能是间质性肾炎病因中的一个因素。
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