Menezes Sharleen V, Sahni Sumit, Kovacevic Zaklina, Richardson Des R
Molecular Pharmacology and Pathology Program, Department of Pathology, Bosch Institute, University of Sydney, Sydney, New South Wales 2006, Australia.
Molecular Pharmacology and Pathology Program, Department of Pathology, Bosch Institute, University of Sydney, Sydney, New South Wales 2006, Australia.
J Biol Chem. 2017 Aug 4;292(31):12772-12782. doi: 10.1074/jbc.R117.776393. Epub 2017 Jun 14.
The iron-regulated metastasis suppressor N-myc downstream-regulated gene 1 (NDRG1) has been shown to inhibit numerous oncogenic signaling pathways in cancer cells. Recent findings have demonstrated that NDRG1 inhibits the ErbB family of receptors, which function as key inducers of carcinogenesis. NDRG1 attenuates ErbB signaling by inhibiting formation of epidermal growth factor receptor (EGFR)/human epidermal growth factor receptor 2 (HER2) and HER2/HER3 heterodimers and by down-regulating EGFR via a mechanism involving its degradation. Understanding the complex interplay between NDRG1, iron, and ErbB signaling is vital for identifying novel, more effective targets for cancer therapy.
铁调节的转移抑制因子N-myc下游调节基因1（NDRG1）已被证明可抑制癌细胞中的多种致癌信号通路。最近的研究结果表明，NDRG1可抑制作为致癌作用关键诱导因子的ErbB受体家族。NDRG1通过抑制表皮生长因子受体（EGFR）/人表皮生长因子受体2（HER2）和HER2/HER3异二聚体的形成，并通过一种涉及其降解的机制下调EGFR，从而减弱ErbB信号传导。了解NDRG1、铁和ErbB信号传导之间的复杂相互作用对于确定癌症治疗的新的、更有效的靶点至关重要。
