Coskunoglu Aysun, Orenay-Boyacioglu Seda, Deveci Artuner, Bayam Mustafa, Onur Ece, Onan Arzu, Cam Fethi S
Department of Medical Genetics, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
Department of Medical Genetics, Faculty of Medicine, Adnan Menderes University, Efeler, Aydin, Turkey.
Noise Health. 2017 May-Jun;19(88):140-148. doi: 10.4103/nah.NAH_74_16.
Brain-derived neurotrophic factor (BDNF) gene polymorphisms are associated with abnormalities in regulation of BDNF secretion. Studies also linked BDNF polymorphisms with changes in brainstem auditory-evoked response test results. Furthermore, BDNF levels are reduced in tinnitus, psychiatric disorders, depression, dysthymic disorder that may be associated with stress, conversion disorder, and suicide attempts due to crises of life. For this purpose, we investigated whether there is any role of BDNF changes in the pathophysiology of tinnitus.
In this study, we examined the possible effects of BDNF variants in individuals diagnosed with tinnitus for more than 3 months. Fifty-two tinnitus subjects between the ages of 18 and 55, and 42 years healthy control subjects in the same age group, who were free of any otorhinolaryngology and systemic disease, were selected for examination. The intensity of tinnitus and depression was measured using the tinnitus handicap inventory, and the differential diagnosis of psychiatric diagnoses made using the Structured Clinical Interview for Fourth Edition of Mental Disorders. BDNF gene polymorphism was analyzed in the genomic deoxyribonucleic acid (DNA) samples extracted from the venous blood, and the serum levels of BDNF were measured. One-way analysis of variance and Chi-squared tests were applied.
Serum BDNF level was found lower in the tinnitus patients than controls, and it appeared that there is no correlation between BDNF gene polymorphism and tinnitus.
This study suggests neurotrophic factors such as BDNF may have a role in tinnitus etiology. Future studies with larger sample size may be required to further confirm our results.
脑源性神经营养因子（BDNF）基因多态性与BDNF分泌调节异常有关。研究还将BDNF多态性与脑干听觉诱发电位测试结果的变化联系起来。此外，在耳鸣、精神疾病、抑郁症、可能与压力相关的心境恶劣障碍、转换障碍以及因生活危机导致的自杀企图中，BDNF水平会降低。为此，我们研究了BDNF变化在耳鸣病理生理学中是否起作用。
在本研究中，我们检查了BDNF变异体对诊断为耳鸣超过3个月的个体的可能影响。选取了52名年龄在18至55岁之间的耳鸣患者以及42名同年龄组的健康对照者进行检查，这些对照者无任何耳鼻喉科和全身性疾病。使用耳鸣障碍量表测量耳鸣和抑郁的强度，并使用《精神障碍诊断与统计手册》第四版的结构化临床访谈进行精神疾病的鉴别诊断。对从静脉血中提取的基因组脱氧核糖核酸（DNA）样本进行BDNF基因多态性分析，并测量血清BDNF水平。应用单因素方差分析和卡方检验。
发现耳鸣患者的血清BDNF水平低于对照组，并且BDNF基因多态性与耳鸣之间似乎没有相关性。
本研究表明BDNF等神经营养因子可能在耳鸣病因中起作用。未来可能需要更大样本量的研究来进一步证实我们的结果。
