Tramboo S R, Shahardar R A, Allaie I M, Wani Z A, Abbas Maria
Division of Veterinary Parasitology, FVSc. & AH., SKUAST-K, Shuhama Campus (Alusteng), Srinagar, 190006 India.
J Parasit Dis. 2017 Jun;41(2):380-382. doi: 10.1007/s12639-016-0810-5. Epub 2016 Jul 15.
The present work was undertaken to evaluate the therapeutic efficacy of ivermectin, closantel and fenbendazole under field conditions against Gastrointestinal Nematodes (GIN) of cross bred merino sheep in Budgam area of Kashmir Valley. A total of 115 sheep having Egg per gram of faeces (EPG) greater than or equal to 150 (mean EPG 258.89) were selected. The animals were randomly divided into four groups comprising of 30 animals each in three treatment groups (ivermectin, closantel and fenbendazole) and twenty-five in fourth untreated infected control group. Faecal samples from the selected animals were collected on day '0' pre treatment and on days 8th and 14th post treatment. Based on Faecal Egg Count Reduction Test (FECRT), ivermectin was found to be 98.80 % effective against strongyles on 8th day post treatment, however an efficacy of 100 % was seen against strongyle worms on 14th day post treatment. 98.80 and 100 % efficacy was observed on day 8th post treatment against strongyles in case of closantel and fenbendazole respectively, however efficacy decreased to 97.60 and 98.8 % respectively on 14th day post treatment. There was no evidence of development of resistance by GIN of cross bred merino sheep in District Budgam of Kashmir Valley to ivermectin, closantel and fenbendazole.
本研究旨在评估伊维菌素、氯氰碘柳胺钠和芬苯达唑在田间条件下对克什米尔山谷布德加姆地区杂交美利奴羊胃肠道线虫（GIN）的治疗效果。共选择了115只每克粪便虫卵数（EPG）大于或等于150（平均EPG为258.89）的绵羊。这些动物被随机分为四组，三个治疗组每组30只动物（分别使用伊维菌素、氯氰碘柳胺钠和芬苯达唑），第四组为25只未治疗的感染对照组。在治疗前第0天以及治疗后第8天和第14天收集所选动物的粪便样本。根据粪便虫卵计数减少试验（FECRT），发现伊维菌素在治疗后第8天对圆线虫的有效率为98.80%，然而在治疗后第14天对圆线虫的有效率为100%。氯氰碘柳胺钠和芬苯达唑在治疗后第8天对圆线虫的有效率分别为98.80%和100%，但在治疗后第14天有效率分别降至97.60%和98.8%。没有证据表明克什米尔山谷布德加姆地区的杂交美利奴羊的胃肠道线虫对伊维菌素、氯氰碘柳胺钠和芬苯达唑产生了抗药性。
