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睑板腺形态及睑裂斑炎患者眼高阶像差的变化

Changes in meibomian gland morphology and ocular higher-order aberrations in eyes with chalazion.

作者信息

Fukuoka Shima, Arita Reiko, Shirakawa Rika, Morishige Naoyuki

机构信息

Department of Ophthalmology, Omiya Hamada Eye Clinic.

Lid and Meibomian Gland Working Group (LIME), Saitama-shi, Saitama.

出版信息

Clin Ophthalmol. 2017 May 30;11:1031-1038. doi: 10.2147/OPTH.S133060. eCollection 2017.

DOI:10.2147/OPTH.S133060
PMID:28615923
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5460643/
Abstract

PURPOSE

To examine the changes in meibomian gland morphology and ocular higher-order aberrations (HOAs) in eyes with chalazion and its excision.

METHODS

Seven male patients with previous history of chalazion excision and seven control male subjects were enrolled. Changes in meibomian gland morphology (meiboscores, gland dropout, and shortening) were evaluated by using meibography equipped in a wavefront analyzer KR-1W and in a slit-lamp device BG-4M. Ocular HOAs were measured sequentially with KR-1W. The tear film breakup time (BUT) was measured.

RESULTS

Both KR-1W and BG-4M visualized meibomian gland as clear similar images. The tear film BUT (mean ± SD, 5.6±3.0 vs 9.4±2.3 seconds, =0.025), the total meiboscore (median [interquartile range], 2 (2-3) vs 0 (0-1), =0.007) as well as the meibomian gland dropout rate (86% vs 14%, =0.008) and shortening rate (100% vs 29%, =0.031) differed significantly between the patient and control groups. The first total ocular HOAs (0.142±0.063 vs 0.130±0.015, =0.80) were similar in both groups, whereas the stability index of the total HOAs over time (0.0041±0.0048 vs -0.0012±0.0020, =0.030) differed significantly between the patient and control groups.

CONCLUSIONS

Chalazion and its excision were associated with dropout and shortening rate of meibomian glands. The morphological changes of meibomian glands in chalazion may be associated to instability of the tear film, which was suggested by the tear film BUT and the stability of ocular HOAs.

摘要

目的

研究睑板腺囊肿及其切除术后睑板腺形态和眼高阶像差（HOAs）的变化。

方法

纳入7例有睑板腺囊肿切除史的男性患者和7例对照男性受试者。使用配备在波前分析仪KR - 1W和裂隙灯装置BG - 4M中的睑板腺照相术评估睑板腺形态的变化（睑板腺评分、腺体缺失和缩短）。用KR - 1W依次测量眼HOAs。测量泪膜破裂时间（BUT）。

结果

KR - 1W和BG - 4M均能清晰显示相似的睑板腺图像。患者组和对照组的泪膜BUT（平均值±标准差，5.6±3.0秒对9.4±2.3秒，P = 0.025）、睑板腺总评分（中位数[四分位间距]，2（2 - 3）对0（0 - 1），P = 0.007）以及睑板腺缺失率（86%对14%，P = 0.008）和缩短率（100%对29%，P = 0.031）差异有统计学意义。两组的首次总眼HOAs（0.142±0.063对0.130±0.015，P = 0.80）相似，而患者组和对照组之间总HOAs随时间的稳定性指数（0.0041±0.0048对 - 0.0012±0.0020，P = 0.030）差异有统计学意义。

结论

睑板腺囊肿及其切除术与睑板腺的缺失和缩短率有关。睑板腺囊肿中睑板腺的形态变化可能与泪膜不稳定有关，泪膜BUT和眼HOAs的稳定性提示了这一点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/118b/5460643/28a95ab560cc/opth-11-1031Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/118b/5460643/daec8347abb2/opth-11-1031Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/118b/5460643/216314461491/opth-11-1031Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/118b/5460643/28a95ab560cc/opth-11-1031Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/118b/5460643/daec8347abb2/opth-11-1031Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/118b/5460643/216314461491/opth-11-1031Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/118b/5460643/28a95ab560cc/opth-11-1031Fig3.jpg

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