RASSF1A methylation, YAP1 activation and metastasis: a new role for an old foe in lung cancer.
作者信息
Oh Min Hee, Lockwood William W
机构信息
Department of Integrative Oncology, British Columbia Cancer Agency, Vancouver, Canada.
Interdisciplinary Oncology Program, University of British Columbia, Vancouver, Canada.
出版信息
J Thorac Dis. 2017 May;9(5):1165-1167. doi: 10.21037/jtd.2017.04.16.
Abstract
摘要
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本文引用的文献
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RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non-Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway.RASSF1A 通过 GEF-H1/RhoB 通路抑制 YAP 激活从而抑制人非小细胞肺癌细胞的侵袭和转移潜能。
Cancer Res. 2016 Mar 15;76(6):1627-40. doi: 10.1158/0008-5472.CAN-15-1008. Epub 2016 Jan 12.
2
Mechanistic insight into GPCR-mediated activation of the microtubule-associated RhoA exchange factor GEF-H1.深入了解 G 蛋白偶联受体（GPCR）介导的微管相关 RhoA 交换因子 GEF-H1 的激活机制。
Nat Commun. 2014 Sep 11;5:4857. doi: 10.1038/ncomms5857.
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Comprehensive molecular profiling of lung adenocarcinoma.肺腺癌的全面分子分析。
Nature. 2014 Jul 31;511(7511):543-50. doi: 10.1038/nature13385. Epub 2014 Jul 9.
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KRAS and YAP1 converge to regulate EMT and tumor survival.KRAS 和 YAP1 共同调控 EMT 和肿瘤存活。
Cell. 2014 Jul 3;158(1):171-84. doi: 10.1016/j.cell.2014.06.004. Epub 2014 Jun 19.
5
Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations.人类肺上皮细胞通过特定的致癌操作进展为恶性肿瘤。
Mol Cancer Res. 2013 Jun;11(6):638-50. doi: 10.1158/1541-7786.MCR-12-0634-T. Epub 2013 Feb 28.
6
The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1.假定的肿瘤抑制因子RASSF1A与Ras-GTP结合蛋白Nore1形成同二聚体和异二聚体。
Oncogene. 2002 Feb 21;21(9):1381-90. doi: 10.1038/sj.onc.1205192.
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Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3.来自肺癌抑癌基因座3p21.3的RAS关联结构域家族蛋白的表观遗传失活。
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