Klimek L, Becker S
Zentrum für Rhinologie und Allergologie Wiesbaden, Wiesbaden, Deutschland.
Hals‑, Nasen‑, Ohrenklinik und Poliklinik, Universitätsmedizin Mainz, Langenbeckstr. 1, 55131, Mainz, Deutschland.
HNO. 2017 Oct;65(10):818-825. doi: 10.1007/s00106-017-0372-6.
Molecular component-resolved diagnostics (CRD) are, in addition to its research applications, being increasingly used in daily allergological routine. CRD offers improved diagnostic accuracy via a better understanding of the underlying allergen causing symptoms and helps to distinguish between true sensitization and cross reactions in polysensitized patients, thereby providing an approach for individual personalized therapy. Particularly in food allergies and anaphylaxis, CRD can stratify risks for the recurrence of reactions and their severity. The education and extended vocational training of clinical allergologists has to keep pace with the tremendous increase of knowledge in the field of molecular allergology.
分子成分解析诊断（CRD）除了在研究应用中使用外，在日常过敏症诊疗中也越来越多地被采用。CRD通过更好地理解引发症状的潜在过敏原提高诊断准确性，有助于区分多敏患者的真正致敏和交叉反应，从而为个性化治疗提供方法。特别是在食物过敏和过敏反应中，CRD可以对反应复发风险及其严重程度进行分层。临床过敏症专科医生的教育和扩展职业培训必须跟上分子过敏学领域知识的迅猛增长。
