Guven Yilmaz Suzan, Degirmenci Cumali, Karakoyun Yunus Emre, Yusifov Emil, Ates Halil
Department of Ophthalmology, Faculty of Medicine, Ege University, Izmir, Turkey.
Department of Ophthalmology, School of Medicine, Ege University, 35100, Bornova, Izmir, Turkey.
Int Ophthalmol. 2018 Aug;38(4):1425-1431. doi: 10.1007/s10792-017-0601-8. Epub 2017 Jun 14.
To evaluate the effect of bimatoprost/timolol maleate fixed combination (BTFC), latanoprost/timolol maleate fixed combination (LTFC), and travoprost/timolol maleate fixed combination (TTFC) on 24-h intraocular pressure (IOP) in patients with open-angle glaucoma.
This prospective, observer-masked, randomized study included 50 patients with primary open-angle glaucoma. All patients were using hypotensive lipids and timolol maleate fixed combination treatment for ≥4 weeks and had an IOP ≤ 21 mmHg. Group 1 (n = 18) received BTFC, group 2 (n = 14) received LTFC, and group 3 (n = 18) received TTFC. All patients were hospitalized, and IOP was monitored for 24-h (10:00, 14:00, 18:00, 22:00, 02:00, and 06:00). Mean diurnal IOP variation measurements were taken between 06:00 and 18:00, and mean nocturnal IOP variation measurements were taken between 22:00 and 02:00. Mean IOP and IOP variation in the three groups were compared.
Mean 24-h IOP did not differ significantly between the three groups (group 1: 14.6 ± 2.9 mmHg; group 2: 14.1 ± 3.7 mmHg and group 3: 15.8 ± 2.0 mmHg; P > 0.05). Mean diurnal IOP variation was 4.6 ± 2.3 mmHg in group 1, 5.8 ± 2.4 mmHg in group 2, and 4.3 ± 1.7 mmHg in group 3, and mean nocturnal IOP variation was 3.2 ± 2.8 mmHg in group 1, 2.9 ± 1.9 mmHg in group 2, and 3.0 ± 1.6 mmHg group 3. There were not any significant differences in diurnal or nocturnal IOP variation between the three groups (P < 0.05).
All three fixed combinations effectively controlled IOP for 24-h and had a similar effect on diurnal and nocturnal IOP variations.
评估比马前列素/马来酸噻吗洛尔固定复方制剂（BTFC）、拉坦前列素/马来酸噻吗洛尔固定复方制剂（LTFC）和曲伏前列素/马来酸噻吗洛尔固定复方制剂（TTFC）对开角型青光眼患者24小时眼压（IOP）的影响。
这项前瞻性、观察者设盲、随机研究纳入了50例原发性开角型青光眼患者。所有患者均使用降眼压药物和马来酸噻吗洛尔固定复方制剂治疗≥4周，且眼压≤21 mmHg。第1组（n = 18）接受BTFC，第2组（n = 14）接受LTFC，第3组（n = 18）接受TTFC。所有患者均住院治疗，并监测24小时眼压（10:00、14:00、18:00、22:00、02:00和06:00）。日间眼压变化均值在06:00至18:00之间测量，夜间眼压变化均值在22:00至02:00之间测量。比较三组的平均眼压和眼压变化。
三组之间的24小时平均眼压无显著差异（第1组：14.6±2.9 mmHg；第2组：14.1±3.7 mmHg；第3组：15.8±2.0 mmHg；P>0.05）。第1组日间眼压变化均值为4.6±2.3 mmHg，第2组为5.8±2.4 mmHg，第3组为4.3±1.7 mmHg；第1组夜间眼压变化均值为3.2±2.8 mmHg，第2组为2.9±1.9 mmHg，第3组为3.0±1.6 mmHg。三组之间日间或夜间眼压变化无显著差异（P<0.05）。
所有三种固定复方制剂均能有效控制24小时眼压，且对日间和夜间眼压变化的影响相似。
