钯催化的芳基磺酰基腙与末端炔烃的脱硫交叉偶联：一种构建官能化内部炔烃的通用方法。

Palladium-Catalyzed Desulfitative Cross-Coupling of Arylsulfonyl Hydrazides with Terminal Alkynes: A General Approach toward Functionalized Internal Alkynes.

机构信息

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University , Changsha 410082, Hunan, China.

College of Chemistry and Materials Engineering, Wenzhou University , Wenzhou 325035, Zhejiang, China.

出版信息

J Org Chem. 2017 Jul 7;82(13):6764-6769. doi: 10.1021/acs.joc.7b00899. Epub 2017 Jun 27.

DOI:10.1021/acs.joc.7b00899

PMID:28616974

Abstract

A palladium-catalyzed Sonogashira-type coupling between arylsulfonyl hydrazides and terminal alkynes via Ar(C)-S bond cleavage is disclosed, which enables the general synthesis of functionalized internal alkynes, especially the Br-substituted ones, in good to excellent yields under acid- and base-free conditions.

摘要

本文公开了一种钯催化的芳基磺酰基腙与末端炔烃的 Sonogashira 型偶联反应，通过 Ar(C)-S 键断裂实现，在无酸和无碱条件下能够以良好至优秀的收率得到官能化的内炔烃，特别是 Br 取代的内炔烃。