Xu Silin, Zhang Zhenming, Han Chunyu, Hu Wenkai, Xiao Tiwen, Yuan Yanan, Zhao Junfeng
College of Chemistry and Chemical Engineering , Jiangxi Normal University , Nanchang 330022 , People's Republic of China.
J Org Chem. 2019 Sep 20;84(18):12192-12197. doi: 10.1021/acs.joc.9b01877. Epub 2019 Sep 10.
A highly efficient palladium-catalyzed Sonogashira coupling of benzylic ammonium salts with terminal alkynes is developed. This strategy provides a facile access to a series of internal alkyne derivatives in moderate to excellent yields via C-N bond cleavage and C(sp)-C(sp) bond formation. The broad substrate scope and high functional group tolerance make this reaction attractive for organic synthesis.
开发了一种高效的钯催化苄基铵盐与末端炔烃的Sonogashira偶联反应。该策略通过C-N键断裂和C(sp)-C(sp)键形成，以中等至优异的产率提供了一种简便的方法来合成一系列内炔衍生物。广泛的底物范围和高官能团耐受性使该反应在有机合成中具有吸引力。
