Arbi Sandra, Oberholzer Hester Magdalena, Van Rooy Mia Jeanne, Venter Chantelle, Bester Megan Jean
a Department of Anatomy, Faculty of Health Sciences , University of Pretoria , Pretoria , South Africa.
b Department of Physiology, Faculty of Health Sciences , University of Pretoria , Pretoria , South Africa.
Ultrastruct Pathol. 2017 Jul-Aug;41(4):275-283. doi: 10.1080/01913123.2017.1327909. Epub 2017 Jun 15.
Water contamination with heavy metals may adversely affect our health. High metal levels lead to changes in blood coagulation processes, increasing the risk for cardiovascular disease. Exposure is not limited to a single metal but usually involves a mixture of metals. In this study 24 male Sprague-Dawley rats were exposed to cadmium (Cd) and mercury (Hg), alone and in combination, for 28 days at dosages equivalent to 1000 times the World Health Organization water limits. Scanning electron microscopy analysis revealed that both metals caused platelet activation. Cd significantly increased fibrin fibers thickness and caused aggregation and formation of dense matted deposits (DMDs). Hg reduced fibrin network formation. In the combination group, Hg appeared to augment the effect of Cd, and the presence of extensive DMDs or aggregates between the fibers, with no changes to the actual fibrin thickness, was observed.
重金属对水的污染可能会对我们的健康产生不利影响。高金属含量会导致血液凝固过程发生变化，增加患心血管疾病的风险。接触并非仅限于单一金属，通常涉及多种金属的混合物。在本研究中，24只雄性斯普拉格-道利大鼠被单独或联合暴露于镉（Cd）和汞（Hg）中，剂量相当于世界卫生组织水限值的1000倍，持续28天。扫描电子显微镜分析显示，两种金属均会导致血小板活化。镉显著增加纤维蛋白纤维厚度，并导致致密缠结沉积物（DMDs）的聚集和形成。汞减少了纤维蛋白网络的形成。在联合组中，汞似乎增强了镉的作用，并且观察到纤维之间存在大量DMDs或聚集体，而实际纤维蛋白厚度没有变化。
