Indraccolo Ugo, Indraccolo Salvatore Renato, Mignini Fiorenzo
Unità Operativa Complessa di Ostetricia e Ginecologia, Ospedale "Alto Tevere" di Città di Castello, ASL 1 Umbria, Città di Castello, Italy.
Dipartimento di Scienze Ginecologiche, Ostetriche e Urologiche, Sapienza Università di Roma, Rome, Italy.
Ann Ist Super Sanita. 2017 Apr-Jun;53(2):125-134. doi: 10.4415/ANN_17_02_08.
To demonstrate clinical effectiveness of micronized palmitoylethanolamide-trans-polydatin combination in reducing endometriotic chronic pelvic pain. Other endometriotic-pains were also assessed.
Systematic reviews of PubMed, SCIELO, Scopus, and AJOL. Randomized trials and observational studies reporting a visual analogue scale for pain or similar in endometriotic patients were reviewed. A mean improvement of visual analogue scale (or visual analogue scale-like) scores at enrollment and at a three-month follow-up was assessed and interpreted clinically.
Four studies of poor quality were available. In a heterogeneous sample of endometriotic patients with pain, the administration of micronized palmitoylethanolamide/trans-polydatin (400 mg/40 mg) twice a day for three months provided a clinically relevant improvement of chronic pelvic pain and dysmenorrhea while improving deep dyspareunia to a limited degree. No clinically relevant improvement was found for dyschezia.
More studies are warranted for assessing the drugs-related efficacy.
证明微粉化棕榈酰乙醇胺-反式白藜芦醇苷组合在减轻子宫内膜异位症慢性盆腔疼痛方面的临床疗效。还评估了其他子宫内膜异位症相关疼痛。
对PubMed、SCIELO、Scopus和AJOL进行系统评价。纳入报告了子宫内膜异位症患者疼痛视觉模拟量表或类似量表的随机试验和观察性研究。评估并临床解读入组时和三个月随访时视觉模拟量表（或类似视觉模拟量表）评分的平均改善情况。
有四项质量较差的研究。在疼痛的子宫内膜异位症患者的异质性样本中，每天两次服用微粉化棕榈酰乙醇胺/反式白藜芦醇苷（400毫克/40毫克），持续三个月，可使慢性盆腔疼痛和痛经在临床上得到显著改善，同时在一定程度上改善深部性交困难。未发现排便困难有临床显著改善。
需要更多研究来评估药物相关疗效。
