Finale Enrico, Leonardi Giuliana, Auletta Gaetano, Amadori Roberta, Saglietti Chiara, Pagani Leonardo, Guala Andrea
SOC Ostetricia-Ginecologia, Ospedale Castelli, Verbania, Italy.
SOC Ostetricia-Ginecologia, Ospedale SS Pietro e Paolo, Borgosesia, Italy.
Ann Ist Super Sanita. 2017 Apr-Jun;53(2):152-156. doi: 10.4415/ANN_17_02_12.
The aim of this study was to assess whether rubella vaccination immediately after delivery could expose seronegative women to specific untoward effects.
163 rubella-seronegative women received Measles-Mumps-Rubella (MMR) vaccine in the immediate postpartum period; they were evaluated at one month and at three months thereafter through telephone interviews. As controls, we matched 163 rubella-seropositive women, who might experience similar symptoms for any reason in the same timeframe.
No relevant difference was still observed in the frequency of arthralgia and myalgia at one and three months. Instead, a statistically significant difference in the frequency of cervical lymphadenopathy and cutaneous rash at one month (p = 0.028 and p = 0.005, respectively), was observed between cases and controls. However, no statistical differences were reported at three months for the same symptoms.
Postpartum rubella vaccination with MMR is safe and advisable to avoid congenital rubella syndrome.
本研究的目的是评估产后立即接种风疹疫苗是否会使血清学阴性的女性面临特定的不良影响。
163名风疹血清学阴性的女性在产后立即接种了麻疹-腮腺炎-风疹（MMR）疫苗；在接种后1个月和3个月通过电话访谈对她们进行了评估。作为对照，我们匹配了163名风疹血清学阳性的女性，她们可能在同一时间段内因任何原因出现类似症状。
在1个月和3个月时，关节痛和肌痛的发生率仍未观察到相关差异。相反，病例组和对照组在1个月时颈部淋巴结病和皮疹的发生率存在统计学显著差异（分别为p = 0.028和p = 0.005）。然而，对于相同症状，3个月时未报告有统计学差异。
产后接种MMR风疹疫苗是安全的，并且对于避免先天性风疹综合征是可取的。
