Sivolap Yu P
Sechenov First Moscow State Medical University, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2017;117(4):112-116. doi: 10.17116/jnevro20171174112-116.
Panic disorder is a common mental disease with high psychiatric comorbidity. It is considered that a combination of genetic predisposition and a special psychic vulnerability plays a key role in the occurrence of panic disorder. Clinically proven efficacy in the treatment of panic disorder have benzodiazepines, tricyclic antidepressants, monoamine oxidase inhibitors, selective serotonin reuptake inhibitors and selective serotonin and norepinephrine reuptake inhibitors; antidepressants from other pharmaceutical groups are also used. Selective serotonin reuptake inhibitors are the first line medicines in the treatment of panic disorder. Atypical antipsychotics may be used for the therapy augmentation in addition to first line drugs. Psychotherapy is used along with medications, and a combination of pharmacotherapy and cognitive behavioral therapy is the best method of treatment.
惊恐障碍是一种常见的精神疾病，具有较高的精神共病率。人们认为遗传易感性和特殊的心理易损性相结合在惊恐障碍的发生中起关键作用。临床上已证实对惊恐障碍有治疗效果的药物有苯二氮䓬类、三环类抗抑郁药、单胺氧化酶抑制剂、选择性5-羟色胺再摄取抑制剂以及选择性5-羟色胺和去甲肾上腺素再摄取抑制剂；也使用其他药物组的抗抑郁药。选择性5-羟色胺再摄取抑制剂是治疗惊恐障碍的一线药物。非典型抗精神病药除一线药物外可用于增效治疗。心理治疗与药物治疗同时使用，药物治疗与认知行为治疗相结合是最佳治疗方法。
