Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China and State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University, Xiamen 361102, China.
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University, Xiamen 361102, China.
Biomater Sci. 2017 Jul 25;5(8):1512-1516. doi: 10.1039/c7bm00302a.
In this work, a potent photosensitizer, sinoporphyrin sodium (DVDMS), was loaded into RGD-modified ferritin (R-Fn) nanocages by a rapid, scalable and versatile approach for imaging guided photodynamic and photothermal (PTT/PDT) co-therapy. The resulting nanocomposite formed a well-defined nanocage with a photosensitizer loading capacity as high as 66.67 wt%, which far exceeds those reported previously. The bioengineered protein nanocage-based nanotheranostics exhibits a remarkably improved tumor treatment effect over DVDMS with good biocompatibility and the potential of clinical translation.
在这项工作中，一种有效的光敏剂，血卟啉单甲醚钠（DVDMS），通过一种快速、可扩展和通用的方法被装载到 RGD 修饰的铁蛋白（R-Fn）纳米笼中，用于成像引导的光动力和光热（PDT/PTT）联合治疗。所得的纳米复合材料形成了一种具有明确结构的纳米笼，其光敏剂装载能力高达 66.67wt%，远远超过了以前的报道。这种基于生物工程蛋白纳米笼的纳米诊疗剂具有良好的生物相容性和临床转化潜力，表现出比 DVDMS 显著改善的肿瘤治疗效果。
