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用于多模态成像和光热治疗的载染料铁蛋白纳米笼

Dye-loaded ferritin nanocages for multimodal imaging and photothermal therapy.

作者信息

Huang Peng, Rong Pengfei, Jin Albert, Yan Xuefeng, Zhang Molly Gu, Lin Jing, Hu Hao, Wang Zhe, Yue Xuyi, Li Wanwan, Niu Gang, Zeng Wenbin, Wang Wei, Zhou Kechao, Chen Xiaoyuan

机构信息

Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Bethesda, MD, 20892, USA.

出版信息

Adv Mater. 2014 Oct 8;26(37):6401-8. doi: 10.1002/adma.201400914. Epub 2014 Aug 14.

DOI:10.1002/adma.201400914
PMID:25123089
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4215197/
Abstract

Multimodal imaging-guided photothermal therapy (PTT), for the therapy of cancer, based on a ferritin (FRT) nanocage loaded with the near-infrared dye IR820 (designated DFRT) is demonstrated. The dual roles of DFRT (in imaging and PTT) are successfully balanced by using two different excitation wavelengths: 550 nm for high quantum-yield fluorescence imaging on the one hand and 808 nm for photoacoustic imaging and PTT with high photothermal conversion efficiency on the other.

摘要

本文展示了一种基于负载近红外染料IR820的铁蛋白（FRT）纳米笼（命名为DFRT）用于癌症治疗的多模态成像引导光热疗法（PTT）。通过使用两种不同的激发波长，成功平衡了DFRT的双重作用（成像和PTT）：一方面，550 nm用于高量子产率荧光成像；另一方面，808 nm用于光声成像和具有高光热转换效率的PTT。

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本文引用的文献

[1]
Triphase interface synthesis of plasmonic gold bellflowers as near-infrared light mediated acoustic and thermal theranostics.

J Am Chem Soc. 2014-6-11

[2]
Highly efficient hierarchical micelles integrating photothermal therapy and singlet oxygen-synergized chemotherapy for cancer eradication.

Theranostics. 2014-1-29

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Biodegradable gold nanovesicles with an ultrastrong plasmonic coupling effect for photoacoustic imaging and photothermal therapy.

Angew Chem Int Ed Engl. 2013-12-23

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Supramolecular adducts of squaraine and protein for noninvasive tumor imaging and photothermal therapy in vivo.

Biomaterials. 2013-10-26

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Ferritin nanocages: great potential as clinically translatable drug delivery vehicles?

Nanomedicine (Lond). 2013-10

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Near-infrared light-mediated nanoplatforms for cancer thermo-chemotherapy and optical imaging.

Adv Mater. 2013-6-6

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Polypyrrole hollow microspheres as echogenic photothermal agent for ultrasound imaging guided tumor ablation.

Sci Rep. 2013

[8]
Ferritin nanocages to encapsulate and deliver photosensitizers for efficient photodynamic therapy against cancer.

ACS Nano. 2013-7-11

[9]
IR-780 dye loaded tumor targeting theranostic nanoparticles for NIR imaging and photothermal therapy.

Biomaterials. 2013-6-15

[10]
Photosensitizer-loaded gold vesicles with strong plasmonic coupling effect for imaging-guided photothermal/photodynamic therapy.

ACS Nano. 2013-5-30

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