Tang Angcang, Chen Taolin, Zhang Junran, Gong Qiyong, Liu Longqian
J Pediatr Ophthalmol Strabismus. 2017 Sep 1;54(5):303-310. doi: 10.3928/01913913-20170320-05. Epub 2017 Jun 15.
To explore the abnormality of spontaneous activity in patients with anisometropic amblyopia under resting-state functional magnetic resonance imaging (Rs-fMRI).
Twenty-four participants were split into two groups. The anisometropic amblyopia group had 10 patients, all of whom had anisometropic amblyopia of the right eye, and the control group had 14 healthy subjects. All participants underwent Rs-fMRI scanning. Measurement of amplitude of low frequency fluctuations of the brain, which is a measure of the amplitudes of spontaneous brain activity, was used to investigate brain changes between the anisometropic amblyopia and control groups.
Compared with an age- and gender-matched control group, the anisometropic amblyopia group showed increased amplitude of low frequency fluctuations of spontaneous brain activity in the left superior temporal gyrus, the left inferior parietal lobe, the left pons, and the right inferior semi-lunar lobe. The anisometropic amblyopia group also showed decreased amplitude of low frequency fluctuations in the bilateral medial frontal gyrus.
This study demonstrated abnormal spontaneous brain activities in patients with anisometropic amblyopia under Rs-fMRI, and these abnormalities might contribute to the neuropathological mechanisms of anisometropic amblyopia. [J Pediatr Ophthalmol Strabismus. 2017;54(5):303-310.].
探讨屈光参差性弱视患者在静息态功能磁共振成像（Rs-fMRI）下的自发活动异常。
24名参与者被分为两组。屈光参差性弱视组有10名患者，均为右眼屈光参差性弱视，对照组有14名健康受试者。所有参与者均接受Rs-fMRI扫描。通过测量大脑低频波动幅度（这是一种衡量自发脑活动幅度的指标）来研究屈光参差性弱视组与对照组之间的脑变化。
与年龄和性别匹配的对照组相比，屈光参差性弱视组在左侧颞上回、左侧顶下小叶、左侧脑桥和右侧半月小叶的自发脑活动低频波动幅度增加。屈光参差性弱视组双侧额内侧回的低频波动幅度也降低。
本研究表明，在Rs-fMRI下，屈光参差性弱视患者存在异常的自发脑活动，这些异常可能有助于解释屈光参差性弱视的神经病理机制。[《小儿眼科与斜视杂志》。2017；54(5)：303 - 310。]
