Zhang Xiaopan, Liu Liang, Li Yadong, Wang Kejia, Zheng Guangying, Zhang Yong, Cheng Jingliang, Wen Baohong
Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Henan Key Laboratory of Magnetic Resonance and Brain Function, Zhengzhou, 450052, China.
Neuroradiology. 2023 Dec;65(12):1757-1766. doi: 10.1007/s00234-023-03221-x. Epub 2023 Sep 26.
To investigate the abnormal changes of local brain activity in children with right-eye amblyopia of varying degrees.
Data of resting-state functional magnetic resonance imaging were collected from 16 children with severe amblyopia, 17 children with mild to moderate amblyopia, and 15 children with normal binocular vision. Local brain activity was analyzed using the amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo).
There were extensive ALFF differences among the three groups in 10 brain regions. There were extensive differences in ReHo among the three groups in 11 brain regions. The ALFF and ReHo of the right orbital part of the middle frontal gyrus displayed a significantly positive correlation with the best-corrected visual acuity of the right eye, respectively. The ALFF value and ReHo value of the right orbital part of the middle frontal gyrus followed the pattern of normal control < mild to moderate amblyopia < severe amblyopia.
This study demonstrated that there were changes in specific patterns of ALFF and ReHo in children with right-eye amblyopia of different degrees in brain regions performing visual sensorimotor and attentional control functions.
探讨不同程度右眼弱视儿童局部脑活动的异常变化。
收集16例重度弱视儿童、17例轻度至中度弱视儿童和15例双眼视力正常儿童的静息态功能磁共振成像数据。采用低频振幅（ALFF）和局部一致性（ReHo）分析局部脑活动。
三组在10个脑区存在广泛的ALFF差异。三组在11个脑区的ReHo存在广泛差异。额中回右侧眶部的ALFF和ReHo分别与右眼最佳矫正视力呈显著正相关。额中回右侧眶部的ALFF值和ReHo值遵循正常对照＜轻度至中度弱视＜重度弱视的模式。
本研究表明，不同程度右眼弱视儿童在执行视觉感觉运动和注意力控制功能的脑区中，ALFF和ReHo存在特定模式的变化。
