Goldfine Howard
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
FEBS Lett. 2017 Sep;591(18):2714-2719. doi: 10.1002/1873-3468.12714. Epub 2017 Jul 4.
The biosynthesis of plasmalogens in anaerobic bacteria differs fundamentally from that in animal cells. Firstly, the formation of the alk-1'-enyl ether bond in animal cells is oxygen dependent. Secondly, the first step in plasmalogen formation in animal cells is an acylation of dihydroxyacetone phosphate, which has been ruled out as a precursor in anaerobes. In bacteria the alk-1'-enyl ether bond is formed after the fully formed acyl glycerolipids are synthesized. Evidence will be presented for the conversion of the sn-1 acyl-linked chain to an O-alk-1'-enyl ether by an as yet unknown mechanism.
厌氧细菌中缩醛磷脂的生物合成与动物细胞中的生物合成有着根本的不同。首先，动物细胞中alk-1'-烯基醚键的形成依赖于氧气。其次，动物细胞中缩醛磷脂形成的第一步是磷酸二羟丙酮的酰化反应，而这一反应在厌氧菌中已被排除在其前体反应之外。在细菌中，alk-1'-烯基醚键是在完全合成酰基甘油脂质后形成的。将通过一种尚不明确的机制，展示sn-1酰基连接链转化为O-alk-1'-烯基醚的证据。
