Department of Endocrinology, Army Hospital (Research and Referral), Delhi, India.
Department Pediatrics, Army Hospital (Research and Referral), Delhi, India.
Clin Endocrinol (Oxf). 2017 Nov;87(5):605-608. doi: 10.1111/cen.13395. Epub 2017 Jul 24.
Detailed information on the epidemiology of parathyroid disorders in India is lacking. Most of the available data pertain to primary hyperparathyroidism (PHPT) rather than the overall burden of parathyroid disorders. We studied the incidence of parathyroid disorders in a cohort of service personnel followed for a long duration.
DESIGN, SETTING AND PATIENTS: The data for this retrospective, descriptive epidemiological study were derived from the electronic medical records (EMR) of health care personnel enrolled between 1990 and 2015. Subjects were recruited between the ages of 17 and 20 years in good health, and the data pertaining to parathyroid disorders were derived from the EMR.
We calculated the incidence rates per person-years of parathyroid disorders using appropriate statistical methods.
Our analysis includes 51 217 participants (median age 33, range 17-54 years) with a mean follow-up of 12.5 years. Yearly evaluation of the data gave cumulative follow-up duration of 613 925 person-years. PHPT was diagnosed in 37 patients and hypoparathyroidism in 16 patients, giving incidence rates of 6 and 2.6 per 100 000 person-years, respectively. Only one patient was diagnosed with pseudohypoparathyroidism (0.16 per 100 000 person-years). Of the 37 patients with PHPT, 16 (43%) developed postsurgical hypoparathyroidism.
Our cohort had a low incidence of PHPT when compared to Western populations. Long-term epidemiological studies are essential to identify the demographic trends of metabolic bone disorders in India.
印度有关甲状旁腺疾病的流行病学详细信息较为缺乏。大部分现有数据与原发性甲状旁腺功能亢进症（PHPT）相关，而非整体甲状旁腺疾病负担。我们研究了在长期随访的服务人员队列中甲状旁腺疾病的发病率。
设计、设置和患者：本回顾性描述性流行病学研究的数据来自于 1990 年至 2015 年间入组的医务人员电子病历（EMR）。受试者年龄在 17 至 20 岁之间，身体健康，甲状旁腺疾病相关数据来源于 EMR。
我们使用适当的统计方法计算了甲状旁腺疾病的人年发病率。
我们的分析包括 51217 名参与者（中位数年龄 33 岁，范围 17-54 岁），平均随访 12.5 年。每年对数据进行评估，累计随访时间为 613925 人年。37 例患者被诊断为 PHPT，16 例患者被诊断为甲状旁腺功能减退症，发病率分别为 6 和 2.6 例/10 万患者年。仅 1 例患者被诊断为假性甲状旁腺功能减退症（0.16 例/10 万患者年）。37 例 PHPT 患者中，16 例（43%）术后发生甲状旁腺功能减退症。
与西方人群相比，我们的队列 PHPT 发病率较低。长期的流行病学研究对于确定印度代谢性骨疾病的人口统计学趋势至关重要。
