Haas J F, Cope D N
Arch Phys Med Rehabil. 1985 Jul;66(7):472-4.
A patient with traumatic head injury was confused, agitated, and belligerent. Initial treatment with sedatives (diazepam) and antipsychotics (haloperidol and thioridazine hydrochloride) did not diminish this irritability or destructive behavior. A single case experimental methodology was adopted to evaluate the behavioral response to other sequentially introduced neuroactive drugs. Methylphenidate produced increased agitation. No response was noted to propranolol. Lithium, however, was associated with significant calming of the patient, successful completion of rehabilitation, and discharge to home where the patient safely cared for himself while his wife worked.
一名创伤性脑损伤患者出现意识模糊、烦躁不安且好斗。最初使用镇静剂（地西泮）和抗精神病药物（氟哌啶醇和盐酸硫利达嗪）进行治疗，并未减轻其易怒或破坏性行为。采用单病例实验方法来评估患者对其他依次引入的神经活性药物的行为反应。哌甲酯使烦躁加剧。未观察到普萘洛尔有反应。然而，锂盐使患者明显平静下来，成功完成康复并出院回家，在其妻子工作时患者能安全地自我照料。
