Mourad Moustafa, Jetmore Thomas, Jategaonkar Ameya A, Moubayed Sami, Moshier Erin, Urken Mark L
Resident, Department of Otolaryngology-Head and Neck Surgery, New York Eye and Ear Infirmary of Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY.
Resident, Department of Otolaryngology-Head and Neck Surgery, Indiana University, Indianapolis, IN.
J Oral Maxillofac Surg. 2017 Dec;75(12):2562-2572. doi: 10.1016/j.joms.2017.05.008. Epub 2017 May 22.
This study represents the most recent epidemiologic trends of head and neck cancer (HNC) in the United States. It provides an important discussion on oropharyngeal cancer and cancers related to the human papillomavirus. The objective was to identify trends in HNC (2002 to 2012) within the United States.
This study is a retrospective analysis of the US National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) submission. Using the November 2014 submission of the SEER database and SEER-18 data files, data from 2002 to 2012 were analyzed to determine the most recent epidemiologic trends. HNCs of all subtypes were analyzed together. Laryngeal cancers were further analyzed separately. Oropharyngeal cancers of the base of tongue and tonsil were analyzed independently to attempt to trend HPV-related cancers.
From 2002 to 2012, there were 149,301 cases of HNC recorded in the SEER database. The HNC rate decreased by 0.22% per year (P = .0549) and the rate of laryngeal cancer decreased by 1.9% per year (P < .0001). The rate of oropharyngeal (HPV-related) cancer increased by 2.5% per year (P < .0001). HNC rates increased significantly in Kentucky and Connecticut and decreased in California (P < .05). HPV-related cancers increased significantly in all states except Georgia, Hawaii, and Michigan (P < .05). Laryngeal cancer rates decreased in California, Georgia, New Jersey, and New Mexico (P < .05).
The overall incidence of HNC is decreasing in the United States. There is an increasing incidence of HPV-related cancers of the oropharynx. Meaningful differences in cancer incidence and rate of change exist between men and women. Furthermore, younger groups have a greater decrease of overall HNC, with an overall increase in HPV-related cancer in patients older than 50 years.
本研究呈现了美国头颈癌（HNC）的最新流行病学趋势。它对口咽癌及与人乳头瘤病毒相关的癌症进行了重要探讨。目的是确定美国境内HNC（2002年至2012年）的趋势。
本研究是对美国国立癌症研究所监测、流行病学和最终结果（SEER）数据提交的回顾性分析。利用2014年11月提交的SEER数据库和SEER - 18数据文件，分析2002年至2012年的数据以确定最新的流行病学趋势。所有亚型的HNC一起进行分析。喉癌进一步单独分析。舌根部和扁桃体的口咽癌独立分析以试图追踪与人乳头瘤病毒相关的癌症趋势。
2002年至2012年，SEER数据库记录了149,301例HNC病例。HNC发病率每年下降0.22%（P = 0.0549），喉癌发病率每年下降1.9%（P < 0.0001）。口咽（与人乳头瘤病毒相关）癌发病率每年上升2.5%（P < 0.0001）。肯塔基州和康涅狄格州的HNC发病率显著上升，加利福尼亚州下降（P < 0.05）。除佐治亚州、夏威夷州和密歇根州外，所有州与人乳头瘤病毒相关的癌症均显著增加（P < 0.05）。加利福尼亚州、佐治亚州、新泽西州和新墨西哥州的喉癌发病率下降（P < 0.05）。
在美国，HNC的总体发病率正在下降。口咽与人乳头瘤病毒相关的癌症发病率在上升。男性和女性在癌症发病率及变化率方面存在显著差异。此外，较年轻群体的总体HNC下降幅度更大，而50岁以上患者中与人乳头瘤病毒相关的癌症总体呈上升趋势。
