Kempf E, Fuhrmann G, Ebel A
Alcohol. 1985 Mar-Apr;2(2):230-7.
Genotypic variations in the reactivity to an acute ethanol intoxication of dopamine turnover, release and metabolites, as well as serotoninergic neurotransmission have been investigated in the nigrostriatal and the septohippocampal pathways of C57Bl and Balb/c mice strains. In the striatum, decreased dopamine release associated with increased DA turnover, was noted after alcohol treatment, possibly as a retrocontrol reaction. Parallely, enhanced serotonin metabolism occurred. For the septohippocampal pathway, dopamine neurotransmission in the septum reacts to alcohol in a similar way as in the striatum. In the hippocampus, serotonin metabolism is reduced. A strain dependent difference in sensitivity to ethanol is observed for both pathways. The results are discussed (1) in the context of interactions of these transmitters with cholinergic activity; (2) in relation with behavioral disturbances associated to alcohol abuse in man (motor incoordination and memory alterations, in particular).
在C57Bl和Balb/c小鼠品系的黑质纹状体和隔海马通路中，已经研究了多巴胺周转、释放和代谢产物以及5-羟色胺能神经传递对急性乙醇中毒反应的基因变异。在纹状体中，酒精处理后发现多巴胺释放减少与多巴胺周转增加有关，这可能是一种逆向控制反应。同时，5-羟色胺代谢增强。对于隔海马通路，隔区的多巴胺神经传递对酒精的反应与纹状体相似。在海马体中，5-羟色胺代谢减少。在这两条通路中均观察到对乙醇敏感性的品系依赖性差异。对这些结果的讨论如下：(1) 基于这些递质与胆碱能活性的相互作用；(2) 与人类酒精滥用相关的行为障碍（特别是运动不协调和记忆改变）有关。
