Bencini A F, Scaf A H, Agoston S, Houwertjes M C, Kersten U W
Br J Anaesth. 1985 Aug;57(8):782-8. doi: 10.1093/bja/57.8.782.
The disposition of vecuronium bromide has been investigated in six normal cats (group I) and in six cats with ligated renal pedicles (group II). A combined fluorimetric and chromatographic technique was used to determine the concentrations of vecuronium and its metabolites in biological material. After i.v. injection of 0.6 mg kg-1, vecuronium disappeared rapidly from the plasma of the normal cat. Concentrations decreased bi-exponentially with half-lives of 4.6 and 31 min, respectively. The steady state volume of distribution was 0.23 litre kg-1 and the clearance 11 ml min-1 kg-1. Seventy percent of an i.v. dose of vecuronium (or its metabolites) was recovered: 15% in the urine, 40% in the bile and 15% in the liver. Only 3.8% of this consisted of the 3-hydroxy metabolite. There were no significant differences in pharmacokinetic data or in the amounts of vecuronium and its metabolites recovered in cats with ligated renal pedicles. The 15% of vecuronium normally excreted by the kidney was compensated for by increased hepatic and biliary concentration of vecuronium.
已在6只正常猫（I组）和6只肾蒂结扎的猫（II组）中研究了维库溴铵的处置情况。采用荧光法和色谱法相结合的技术来测定生物材料中维库溴铵及其代谢物的浓度。静脉注射0.6mg/kg后，维库溴铵迅速从正常猫的血浆中消失。浓度呈双指数下降，半衰期分别为4.6分钟和31分钟。稳态分布容积为0.23升/千克，清除率为11毫升/分钟/千克。静脉注射剂量的70%的维库溴铵（或其代谢物）被回收：15%在尿液中，40%在胆汁中，15%在肝脏中。其中只有3.8%是3-羟基代谢物。肾蒂结扎的猫在药代动力学数据或回收的维库溴铵及其代谢物的量方面没有显著差异。正常情况下由肾脏排泄的15%的维库溴铵通过肝脏和胆汁中维库溴铵浓度的增加得到了补偿。
