From the Medical Research Council Social, Genetic, and Developmental Psychiatry Centre, the Department of Psychology, the Department of Forensic and Neurodevelopmental Sciences, the Addictions Department, and the Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology, and Neuroscience, King's College London; INSERM, UMR 1000, Neuroimaging and Psychiatry Research Unit, University Paris-Sud, University Paris Descartes, Sorbonne Paris Cité, Paris; Maison de Solenn, Paris; the Department of Psychiatry, Orsay Hospital, Orsay, France; the Department of Child and Adolescent Psychiatry and Psychotherapy and the Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neurosciences, Trinity College Dublin; the Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Physikalisch-Technische Bundesanstalt, Braunschweig and Berlin, Germany; the Department of Psychiatry, University of Montreal, CHU Ste. Justine Hospital, Montreal; the Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany; NeuroSpin, CEA (Alternative Energies and Atomic Energy Commission), University Paris-Saclay, Gif-sur-Yvette, France; the Departments of Psychiatry and Psychology, University of Vermont, Burlington; Sir Peter Mansfield Magnetic Resonance Center, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, U.K.; the Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Berlin; AP-HP, Department of Adolescent Psychopathology and Medicine, Maison de Solenn, Cochin Hospital, Paris; Rotman Research Institute, Baycrest, and the Departments of Psychology and Psychiatry, University of Toronto, Toronto; the Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, von-Siebold-Str., Göttingen, Germany; Clinic for Child and Adolescent Psychiatry, Medical University of Vienna, Währinger Gürtel, Vienna; the Department of Psychiatry and the Neuroimaging Center, Technische Universität Dresden, Dresden, Germany; School of Psychology and Global Brain Health Institute, Trinity College Dublin; and the Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behavior, Radboud University Medical Center, and Karakter Child and Adolescent Psychiatry, Nijmegen, the Netherlands.
Am J Psychiatry. 2017 Aug 1;174(8):785-794. doi: 10.1176/appi.ajp.2017.16040464. Epub 2017 Jun 16.
The authors sought to explore how conduct, hyperactivity/inattention, and emotional symptoms are associated with neural reactivity to social-emotional stimuli, and the extent to which psychosocial stress modulates these relationships.
Participants were community adolescents recruited as part of the European IMAGEN study. Bilateral amygdala regions of interest were used to assess the relationship between the three symptom domains and functional MRI neural reactivity during passive viewing of dynamic angry and neutral facial expressions. Exploratory functional connectivity and whole brain multiple regression approaches were used to analyze how the symptoms and psychosocial stress relate to other brain regions.
In response to the social-emotional stimuli, adolescents with high levels of conduct or hyperactivity/inattention symptoms who had also experienced a greater number of stressful life events showed hyperactivity of the amygdala and several regions across the brain. This effect was not observed with emotional symptoms. A cluster in the midcingulate was found to be common to both conduct problems and hyperactivity symptoms. Exploratory functional connectivity analyses suggested that amygdala-precuneus connectivity is associated with hyperactivity/inattention symptoms.
The results link hyperactive amygdala responses and regions critical for top-down emotional processing with high levels of psychosocial stress in individuals with greater conduct and hyperactivity/inattention symptoms. This work highlights the importance of studying how psychosocial stress affects functional brain responses to social-emotional stimuli, particularly in adolescents with externalizing symptoms.
作者试图探讨行为、多动/注意力不集中和情绪症状与对社会情感刺激的神经反应之间的关系，以及社会心理压力在多大程度上调节这些关系。
参与者是作为欧洲 IMAGEN 研究的一部分招募的社区青少年。使用双侧杏仁核感兴趣区来评估三个症状领域与被动观看动态愤怒和中性面部表情时功能磁共振成像神经反应之间的关系。采用探索性功能连接和全脑多元回归方法来分析症状和社会心理压力与其他大脑区域的关系。
在对社会情感刺激的反应中，表现出多动/注意力不集中症状且经历了更多生活压力事件的青少年的杏仁核和大脑其他区域表现出过度活跃。而情绪症状则没有观察到这种现象。中扣带的一个簇被发现与行为问题和多动症状都有关。探索性功能连接分析表明，杏仁核-顶叶下小叶的连接与多动/注意力不集中症状有关。
研究结果将过度活跃的杏仁核反应与对于情绪处理至关重要的区域与具有较高水平的行为问题和多动/注意力不集中症状的个体的高水平社会心理压力联系起来。这项工作强调了研究社会心理压力如何影响对外显症状的个体对社会情感刺激的功能大脑反应的重要性。
