Sundaram Gopinath M, Veera Bramhachari Pallaval
1 Institute of Medical Biology, Agency for Science Technology and Research (A*STAR), Singapore.
2 Department of Biotechnology, Krishna University, Machilipatnam, India.
Tumour Biol. 2017 Jun;39(6):1010428317705760. doi: 10.1177/1010428317705760.
Esophageal squamous cell carcinoma is the sixth most common cancer in the developing world. The aggressive nature of esophageal squamous cell carcinoma, its tendency for relapse, and the poor survival prospects of patients diagnosed at advanced stages, represent a pressing need for the development of new therapies for this disease. Chronic inflammation is known to have a causal link to cancer pre-disposition. Nuclear factor kappa B and signal transducer and activator of transcription 3 are transcription factors which regulate immunity and inflammation and are emerging as key regulators of tumor initiation, progression, and metastasis. Although these pro-inflammatory factors in esophageal squamous cell carcinoma have been well-characterized with reference to protein-coding targets, their functional interactions with non-coding RNAs have only recently been gaining attention. Non-coding RNAs, especially microRNAs and long non-coding RNAs demonstrate potential as biomarkers and alternative therapeutic targets. In this review, we summarize the recent literature and concepts on non-coding RNAs that are regulated by/regulate nuclear factor kappa B and signal transducer and activator of transcription 3 in esophageal cancer progression. We also discuss how these recent discoveries can pave way for future therapeutic options to treat esophageal squamous cell carcinoma.
食管鳞状细胞癌是发展中国家第六大常见癌症。食管鳞状细胞癌具有侵袭性、易复发的特点，且晚期确诊患者的生存前景不佳，这表明迫切需要开发针对该疾病的新疗法。已知慢性炎症与癌症易感性存在因果关系。核因子κB和信号转导及转录激活因子3是调节免疫和炎症的转录因子，正逐渐成为肿瘤起始、进展和转移的关键调节因子。尽管食管鳞状细胞癌中的这些促炎因子在蛋白质编码靶点方面已得到充分表征，但它们与非编码RNA的功能相互作用直到最近才受到关注。非编码RNA，尤其是微小RNA和长链非编码RNA显示出作为生物标志物和替代治疗靶点的潜力。在本综述中，我们总结了近期关于在食管癌进展中受核因子κB和信号转导及转录激活因子3调控/调控核因子κB和信号转导及转录激活因子3的非编码RNA的文献和概念。我们还讨论了这些最新发现如何为未来治疗食管鳞状细胞癌的治疗选择铺平道路。
