Yang Tianli, Li Yang, Zhao Feng, Zhou Liuhua, Jia Ruipeng
Department of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Front Genet. 2021 Mar 23;12:652995. doi: 10.3389/fgene.2021.652995. eCollection 2021.
Circular RNAs (circRNAs) are a class of novel non-coding RNAs (ncRNAs). Emerging evidence demonstrates that circRNAs play crucial roles in many biological processes by regulating linear RNA transcription, downstream gene expression and protein or peptide translation. Meanwhile, recent studies have suggested that circRNAs have the potential to be oncogenic or anti-oncogenic and play vital regulatory roles in the initiation and progression of tumors. Circular RNA Forkhead box O3 (circ-Foxo3, hsa_circ_0006404) is encoded by the human FOXO3 gene and is one of the most studied circular RNAs acting as a sponge for potential microRNAs (miRNAs) (Du et al., 2016). Previous studies have reported that circ-Foxo3 is involved in the development and tumorigenesis of a variety of cancers (bladder, gastric, acute lymphocytic leukemia, glioma, etc.). In this review, we summarize the current studies concerning circ-Foxo3 deregulation and the correlative mechanism in various human cancers. We also point out the potential clinical applications of this circRNA as a biomarker for cancer diagnosis and prognosis.
环状RNA（circRNAs）是一类新型的非编码RNA（ncRNAs）。新出现的证据表明，circRNAs通过调节线性RNA转录、下游基因表达以及蛋白质或肽的翻译，在许多生物学过程中发挥关键作用。同时，最近的研究表明，circRNAs具有致癌或抑癌的潜力，并在肿瘤的发生和发展中发挥重要的调节作用。环状RNA叉头框O3（circ-Foxo3，hsa_circ_0006404）由人类FOXO3基因编码，是研究最多的环状RNA之一，可作为潜在微小RNA（miRNAs）的海绵（Du等人，2016年）。先前的研究报道，circ-Foxo3参与了多种癌症（膀胱癌、胃癌、急性淋巴细胞白血病、胶质瘤等）的发生和肿瘤形成。在本综述中，我们总结了目前关于circ-Foxo3失调及其在各种人类癌症中的相关机制的研究。我们还指出了这种环状RNA作为癌症诊断和预后生物标志物的潜在临床应用。
