From the Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Department of Diagnostic Imaging, The Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Arthritis Imaging Research Group, Department of Radiology, Charité Medical School, Berlin; Radiology, Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany; Department of Radiology and Diagnostic Imaging, and Division of Rheumatology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada; Spire Sciences Inc., Boca Raton, Florida, USA; St. James' University and Chapel Allerton Hospitals; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; University of New South Wales (NSW), Sydney, Australia.
M. Østergaard, MD, PhD, DMSc, Professor, COPECARE, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, University of Copenhagen; I. Eshed, MD, Associate Professor, Department of Diagnostic Imaging, The Sheba Medical Center, Sackler School of Medicine; C.E. Althoff, MD, Senior Consultant, Arthritis Imaging Research Group, Department of Radiology, Charité Medical School; R.P. Poggenborg, MD, PhD, COPECARE, Center for Rheumatology and Spine Diseases, Rigshospitalet; T. Diekhoff, MD, Consultant, Arthritis Imaging Research Group, Department of Radiology, Charité Medical School; S. Krabbe, MD, PhD, COPECARE, Center for Rheumatology and Spine Diseases, Rigshospitalet; S. Weckbach, MD, Professor of Radiology, Diagnostic and Interventional Radiology, University Hospital Heidelberg; R.G. Lambert, MB, BCh, FRCR, FRCPC, Professor, Department of Radiology and Diagnostic Imaging, University of Alberta; S.J. Pedersen, MD, PhD, COPECARE, Center for Rheumatology and Spine Diseases, Rigshospitalet; W.P. Maksymowych, MB, ChB, FRCP(C), Professor, FACP, Division of Rheumatology, Faculty of Medicine and Dentistry, University of Alberta; C.G. Peterfy, MD, PhD, FRCP, Chief Executive Officer, Spire Sciences Inc.; J. Freeston, MD, PhD, Consultant Rheumatologist and Honorary Clinical Associate Professor, St. James' University and Chapel Allerton Hospitals; P. Bird, BMed (Hons), FRACP, PhD, Grad Dip MRI, Associate Professor, University of NSW; P.G. Conaghan, MB, BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Musculoskeletal Biomedical Research Unit; K.G. Hermann, MD, PhD, Senior Consultant, Arthritis Imaging Research Group, Department of Radiology, Charité Medical School.
J Rheumatol. 2017 Nov;44(11):1699-1705. doi: 10.3899/jrheum.161114. Epub 2017 Jun 15.
Whole-body magnetic resonance imaging (WB-MRI) is a relatively new technique that can enable assessment of the overall inflammatory status of people with arthritis, but standards for image acquisition, definitions of key pathologies, and a quantification system are required. Our aim was to perform a systematic literature review (SLR) and to develop consensus definitions of key pathologies, anatomical locations for assessment, a set of MRI sequences and imaging planes for the different body regions, and a preliminary scoring system for WB-MRI in inflammatory arthritis.
An SLR was initially performed, searching for WB-MRI studies in arthritis, osteoarthritis, spondyloarthritis, or enthesitis. These results were presented to a meeting of the MRI in Arthritis Working Group together with an MR image review. Following this, preliminary standards for WB-MRI in inflammatory arthritides were developed with further iteration at the Working Group meetings at the Outcome Measures in Rheumatology (OMERACT) 2016.
The SLR identified 10 relevant original articles (7 cross-sectional and 3 longitudinal, mostly focusing on synovitis and/or enthesitis in spondyloarthritis, 4 with reproducibility data). The Working Group decided on inflammation in peripheral joints and entheses as primary focus areas, and then developed consensus MRI definitions for these pathologies, selected anatomical locations for assessment, agreed on a core set of MRI sequences and imaging planes for the different regions, and proposed a preliminary scoring system. It was decided to test and further develop the system by iterative multireader exercises.
These first steps in developing an OMERACT WB-MRI scoring system for use in inflammatory arthritides offer a framework for further testing and refinement.
全身磁共振成像（WB-MRI）是一种相对较新的技术，能够评估关节炎患者的整体炎症状态，但需要制定图像采集标准、关键病理学定义以及量化系统。我们的目的是进行系统文献回顾（SLR），并制定关键病理学、评估解剖部位、不同身体区域的一套 MRI 序列和成像平面以及炎症性关节炎的初步 WB-MRI 评分系统的共识定义。
最初进行了 SLR，搜索关节炎、骨关节炎、脊柱关节炎或肌腱炎的 WB-MRI 研究。这些结果与关节炎 MRI 工作组的会议一起展示，并进行了 MR 图像审查。在此之后，在 2016 年的风湿病结局测量（OMERACT）工作组会议上，对炎症性关节炎的 WB-MRI 初步标准进行了进一步的迭代制定。
SLR 确定了 10 篇相关的原始文章（7 篇横断面研究和 3 篇纵向研究，主要集中在脊柱关节炎的滑膜炎和/或肌腱炎，其中 4 篇具有可重复性数据）。工作组决定将外周关节和肌腱炎的炎症作为主要关注领域，然后为这些病理学制定共识 MRI 定义，选择评估的解剖部位，为不同区域商定核心 MRI 序列和成像平面，并提出初步评分系统。决定通过迭代多读者练习来测试和进一步开发该系统。
这些制定炎症性关节炎 OMERACT WB-MRI 评分系统的初步步骤为进一步测试和完善提供了框架。
