Xie Yanchen, Li Hai-Feng, Sun Liang, Kusner Linda L, Wang Shuhui, Meng Yunxiao, Zhang Xu, Hong Yu, Gao Xiang, Li Yao, Kaminski Henry J
Department of Neurology, The George Washington University, Washington, DC, United States.
Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Front Neurol. 2017 May 31;8:230. doi: 10.3389/fneur.2017.00230. eCollection 2017.
Biomarkers that assess treatment response for patients with the autoimmune disorder, myasthenia gravis (MG), have not been evaluated to a significant extent. We hypothesized the pro-inflammatory cytokine, osteopontin (OPN), may be associated with variability of response to glucocorticoids (GCs) in patients with MG. A cohort of 250 MG patients treated with standardized protocol of GCs was recruited, and plasma OPN and polymorphisms of its gene, secreted phosphoprotein 1 (), were evaluated. Mean OPN levels were higher in patients compared to healthy controls. Carriers of rs11728697T allele (allele definition: one of two or more alternative forms of a gene) were more frequent in the poorly GC responsive group compared to the GC responsive group indicating an association of rs11728697T allele with GC non-responsiveness. One risk haplotype (AGTACT) was identified associated with GC non-responsiveness compared with GC responsive MG group. Genetic variations of were found associated with the response to GC among MG patients.
评估自身免疫性疾病重症肌无力（MG）患者治疗反应的生物标志物尚未得到充分评估。我们推测促炎细胞因子骨桥蛋白（OPN）可能与MG患者对糖皮质激素（GCs）反应的变异性有关。招募了一组接受GCs标准化方案治疗的250例MG患者，并评估了血浆OPN及其基因分泌磷蛋白1（）的多态性。与健康对照相比，患者的平均OPN水平更高。与GC反应组相比，rs11728697T等位基因（等位基因定义：基因的两个或多个替代形式之一）携带者在GC反应较差组中更为常见，表明rs11728697T等位基因与GC无反应性有关。与GC反应性MG组相比，确定了一种与GC无反应性相关的风险单倍型（AGTACT）。发现的基因变异与MG患者对GC的反应有关。
