Kain Vasundhara, Halade Ganesh V
Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Front Cardiovasc Med. 2017 May 31;4:31. doi: 10.3389/fcvm.2017.00031. eCollection 2017.
Diabetic cardiomyopathy (DCM) or diabetes-induced cardiac dysfunction is a direct consequence of uncontrolled metabolic syndrome and is widespread in US population and worldwide. Despite of the heterogeneous and distinct features of DCM, the clinical relevance of DCM is now becoming established. DCM progresses to pathological cardiac remodeling with the higher risk of heart attack and subsequent heart failure in diabetic patients. In this review, we emphasize lipid substrate quality and the phenotypic, metabolic, and biochemical stressors of DCM in the rodent and human pathophysiology. We discuss lipoxygenase signaling in the inflammatory pathway with multiple contributing and confounding factors leading to DCM. Additionally, emerging biochemical pathways are emphasized to make progress toward therapeutic advancement to treat DCM.
糖尿病性心肌病（DCM）或糖尿病诱导的心脏功能障碍是代谢综合征控制不佳的直接后果，在美国人群和全球范围内广泛存在。尽管DCM具有异质性和独特特征，但DCM的临床相关性目前正在得到确认。DCM会进展为病理性心脏重塑，使糖尿病患者发生心脏病发作和随后心力衰竭的风险更高。在本综述中，我们强调了啮齿动物和人类病理生理学中脂质底物质量以及DCM的表型、代谢和生化应激源。我们讨论了炎症途径中的脂氧合酶信号传导，以及导致DCM的多种促成和混杂因素。此外，还强调了新兴的生化途径，以期在治疗DCM的治疗进展方面取得进展。
