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先天性膈疝新生儿的管理 - 范式转变与伦理问题。

Management of Congenital Diaphragmatic Hernia in Newborn - Paradigm Shift and Ethical Issues.

机构信息

Department of Pediatric Surgery, B.J.Wadia Hospital for Children, Parel, Mumbai, Maharashtra, 400012, India.

Department of Pediatric Surgery, Maulana Azad Medical College, New Delhi, India.

出版信息

Indian J Pediatr. 2017 Aug;84(8):629-635. doi: 10.1007/s12098-017-2374-5. Epub 2017 Jun 16.

Abstract

Management of congenital diaphragmatic hernia (CDH) begins soon after it is detected, whether antenatally or postnatally. Assessment of the severity of the condition, associated congenital anomalies, maternal health and related issues, weight of the fetus/baby, mode of delivery, timing of delivery, immediate appropriate management of the baby with CDH at birth, appropriate utilization of available treatment modalities as well as infrastructure of the treating institute have an impact on the outcome of the neonate. Survival without significant long-term/permanent morbidity is considered as good outcome. With advances in antenatal diagnosis, several legal and ethical considerations have cropped up. While on one hand there are proponents of early antenatal diagnosis and medical termination of pregnancy (MTP), on the other hand there are several socio-cultural groups who look upon human life as precious and argue against MTP. There is an ongoing ethical battle between maternal vs. fetal rights; there is no way to put a lid on the controversy whether the mother be allowed to choose in favor of MTP after being aware of the anomalous fetus or, we must attempt to save every fetus irrespective of the antenatal diagnosis of life-threatening anomalies. Notwithstanding, appropriate assessment of the condition, thorough counseling and sound evidence-based decisions could avert ethical dilemma in most cases. This review article provides information about the various choices available in the diagnostic and treatment armamentarium, though it should be kept in mind that the entire spectrum of management strategies may not be universally available.

摘要

先天性膈疝(CDH)的管理始于发现后,无论是在产前还是产后。评估病情的严重程度、相关的先天性异常、母亲的健康和相关问题、胎儿/婴儿的体重、分娩方式、分娩时机、出生时对患有 CDH 的婴儿进行适当的即时管理、适当利用现有的治疗方法以及治疗机构的基础设施,都会对新生儿的结局产生影响。没有明显的长期/永久性残疾的存活被认为是良好的结果。随着产前诊断的进步,出现了一些法律和伦理方面的考虑。一方面,有人赞成早期产前诊断和人工终止妊娠(MTP),另一方面,也有一些社会文化群体将生命视为宝贵,并反对 MTP。在产妇与胎儿权利之间存在着一场持续的伦理斗争;对于是否应该允许母亲在意识到异常胎儿后选择 MTP,争议难以平息,我们必须尝试挽救每一个胎儿,而不论产前诊断出危及生命的异常情况如何。尽管如此,对病情进行适当评估、进行全面咨询并做出基于证据的明智决策,可以在大多数情况下避免伦理困境。本文综述了在诊断和治疗方面的各种选择,尽管应该记住,并非所有的管理策略都可能普遍适用。

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