Embryology and Stem Cell Biology, Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058, Basel, Switzerland.
Cell Tissue Res. 2018 Jan;371(1):73-89. doi: 10.1007/s00441-017-2641-9. Epub 2017 Jun 15.
Notch signaling is evolutionarily conserved from Drosophila to human. It plays critical roles in neural stem cell maintenance and neurogenesis in the embryonic brain as well as in the adult brain. Notch functions greatly depend on careful regulation and cross-talk with other regulatory mechanisms. Deregulation of Notch signaling is involved in many neurodegenerative diseases and brain disorders. Here, we summarize the fundamental role of Notch in neuronal development and specification and discuss how epigenetic regulation and pathway cross-talk contribute to Notch function. In addition, we cover aberrant alterations of Notch signaling in the diseased brain. The aim of this review is to provide an insight into how Notch signaling works in different contexts to control neurogenesis and its potential effects in diagnoses and therapies of neurodegeneration, brain tumors and disorders.
Notch 信号通路在从果蝇到人类的进化过程中是保守的。它在胚胎大脑和成年大脑中的神经干细胞维持和神经发生中起着关键作用。Notch 的功能很大程度上取决于与其他调节机制的精细调节和相互作用。Notch 信号通路的失调与许多神经退行性疾病和脑部疾病有关。在这里，我们总结了 Notch 在神经元发育和特化中的基本作用，并讨论了表观遗传调控和途径相互作用如何促进 Notch 功能。此外，我们还介绍了 Notch 信号通路在病变大脑中的异常改变。本综述的目的是深入了解 Notch 信号通路在不同环境下如何控制神经发生及其在神经退行性变、脑肿瘤和疾病的诊断和治疗中的潜在影响。
