溃疡性结肠炎相关癌症中的DNA甲基化模式：一项系统综述
DNA methylation patterns in ulcerative colitis-associated cancer: a systematic review.
作者信息
Emmett Ruth A, Davidson Katherine L, Gould Nicholas J, Arasaradnam Ramesh P
机构信息
Warwick Medical School, University of Warwick, Coventry, UK.
Department of Gastroenterology, University Hospital Coventry & Warwick.
出版信息
Epigenomics. 2017 Jul;9(7):1029-1042. doi: 10.2217/epi-2017-0025. Epub 2017 Jun 16.
BACKGROUND
Evidence points to the role of DNA methylation in ulcerative colitis (UC)-associated cancer (UCC), the most serious complication of ulcerative colitis. A better understanding of the etiology of UCC may facilitate the development of new therapeutic targets and help to identify biomarkers of the disease risk.
METHODS
A search was performed in three databases following PRISMA protocol. DNA methylation in UCC was compared with sporadic colorectal cancer (SCRC), and individual genes differently methylated in UCC identified.
RESULTS
While there were some similarities in the methylation patterns of UCC compared with SCRC, generally lower levels of hypermethylation in promoter regions of individual genes was evident in UCC. Certain individual genes are, however, highly methylated in colitis-associated cancer: RUNX3, MINT1, MYOD and p16 exon1 and the promoter regions of EYA4 and ESR.
CONCLUSION
Patterns of DNA methylation differ between UCC and SCRC. Seven genes appear to be promising putative biomarkers.
背景
有证据表明DNA甲基化在溃疡性结肠炎（UC）相关癌症（UCC）中发挥作用，UCC是溃疡性结肠炎最严重的并发症。更好地了解UCC的病因可能有助于开发新的治疗靶点，并有助于识别该疾病风险的生物标志物。
方法
按照PRISMA方案在三个数据库中进行检索。将UCC中的DNA甲基化与散发性结直肠癌（SCRC）进行比较，并鉴定出在UCC中差异甲基化的单个基因。
结果
虽然与SCRC相比，UCC的甲基化模式存在一些相似之处，但UCC中单个基因启动子区域的高甲基化水平总体上较低。然而，某些单个基因在结肠炎相关癌症中高度甲基化：RUNX3、MINT1、MYOD和p16外显子1以及EYA4和ESR的启动子区域。
结论
UCC和SCRC的DNA甲基化模式不同。七个基因似乎是有前景的潜在生物标志物。
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