大鼠主动脉单胺氧化酶和氨基脲敏感胺氧化酶活性的年龄相关变化。
Age-related changes in monoamine oxidase and semicarbazide-sensitive amine oxidase activities of rat aorta.
作者信息
Cao Danh H, Strolin Benedetti M, Dostert P, Mousset A
出版信息
J Pharm Pharmacol. 1985 May;37(5):354-7. doi: 10.1111/j.2042-7158.1985.tb05083.x.
Aorta MAO-A and SSAO activities were measured on young (3 months) and old (23-26 months) rats. A significant decrease (30-40%) in SSAO activity was found with benzylamine as substrate and the decrease was due to a reduction in Vmax. No significant changes in MAO-A activity were found in the aorta of old rats. beta-PEA is oxidized mainly by SSAO in rat aorta. However, the significance of this is unclear since the physiological role of that enzyme remains unknown.
在年轻（3个月）和年老（23 - 26个月）大鼠身上测量了主动脉单胺氧化酶A（MAO - A）和嗜银胺氧化酶（SSAO）的活性。以苄胺为底物时，发现SSAO活性显著降低（30 - 40%），且该降低是由于最大反应速度（Vmax）下降所致。在老年大鼠的主动脉中未发现MAO - A活性有显著变化。在大鼠主动脉中，β - 苯乙胺主要由SSAO氧化。然而，由于该酶的生理作用尚不清楚，所以其意义尚不明确。
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