蟾蜍肝脏线粒体中的单胺氧化酶和氨基脲敏感胺氧化酶活性
Monoamine oxidase and semicarbazide sensitive amine oxidase activities in toad liver mitochondria.
作者信息
Senatori O, Nicotra A
机构信息
Dipartimento di Biologia Animale e dell'Uomo, Università di Roma, Italy.
出版信息
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1988;89(2):257-9. doi: 10.1016/0742-8413(88)90220-4.
PMID:2899004
Abstract
- The deamination of 5-HT and PEA has been assayed by a radiochemical method in mitochondria isolated from toad liver. 2. Time courses of 5-HT and PEA deamination indicate that when PEA is used as the substrate, higher specific activities are obtained. 3. 5-HT is deaminated by MAO A and partially by a SSAO-like enzyme. 4. PEA is deaminated exclusively by SSAO and, MAO B activity, at least under the adopted experimental conditions, is not detectable.
摘要
- 已采用放射化学方法在从蟾蜍肝脏分离的线粒体中测定了5-羟色胺（5-HT）和苯乙胺（PEA）的脱氨基作用。2. 5-HT和PEA脱氨基作用的时间进程表明，当使用PEA作为底物时，可获得更高的比活性。3. 5-HT由单胺氧化酶A（MAO A）脱氨基，部分由一种类胺氧化酶（SSAO）样酶脱氨基。4. PEA仅由SSAO脱氨基，并且至少在所采用的实验条件下，未检测到单胺氧化酶B（MAO B）活性。
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