Street Matthew, Gao Ryan, Martis Waldron, Munro Jacob, Musson David, Cornish Jillian, Ferguson John
Auckland Bone and Joint Research Group, Bone and Joint Research Group, 85 Park Road, Grafton, Auckland 1023, New Zealand.
Auckland Bone and Joint Research Group, Bone and Joint Research Group, 85 Park Road, Grafton, Auckland 1023, New Zealand.
Spine Deform. 2017 Jul;5(4):231-237. doi: 10.1016/j.jspd.2017.02.003.
A systematic review of bone dust as an autologous bone graft to encourage osseous fusion.
To identify and review studies that report on the therapeutic potential of bone dust. The research question was structured as follows: populations-animal and human sources of bone dust harvested using burrs; interventions-autologous bone dust compared with other clinically utilized bone graft options; outcomes assessed-(1) in vitro cell viability, cell differentiation, and osteogenic potential and (2) clinical efficacy in the form of fusion rates as assessed using plain radiographs; study designs-in vitro, preclinical in vivo and clinical studies investigating the therapeutic potential of bone dust, harvested by burring, are included in this systematic review.
Little is known about the efficacy of bone dust, generated during burring of local bone in spine surgery, as a bone graft to encourage osseous union.
A systematic search was conducted in Medline, PubMed, OVID, Scopus, and Cochrane library. The following key words were used: bone dust, bone burring, bone paste, bone pate.
A total of 285 studies were reviewed. Fourteen articles were identified as relevant for inclusion in this systematic review. Current evidence suggests that bone dust retains osteogenic properties, but limited information is available regarding the osteoinductive potential of bone dust.
Bone dust represents a free source of autologous bone, which can be easily collected during the time of surgery and used as an augment to aid osseous fusion. Further research is required to evaluate the osteoinductive potential of bone dust. The retained growth factors in bone dust may potentially induce local osteoprogenitor cells to proliferate and mineralize to form new bone.
对骨屑作为自体骨移植促进骨融合进行系统评价。
识别并综述报告骨屑治疗潜力的研究。研究问题构建如下：研究对象——使用骨钻采集骨屑的动物和人类来源；干预措施——自体骨屑与其他临床应用的骨移植选择进行比较；评估的结果——（1）体外细胞活力、细胞分化和成骨潜力，以及（2）使用X线平片评估的融合率形式的临床疗效；研究设计——本系统评价纳入了研究通过骨钻采集的骨屑治疗潜力的体外、临床前体内和临床研究。
对于脊柱手术中局部骨钻孔产生的骨屑作为促进骨愈合的骨移植材料的疗效知之甚少。
在Medline、PubMed、OVID、Scopus和Cochrane图书馆进行系统检索。使用了以下关键词：骨屑、骨钻孔、骨糊、骨泥。
共检索了285项研究。14篇文章被确定与本系统评价相关并纳入。目前的证据表明骨屑保留了成骨特性，但关于骨屑骨诱导潜力的信息有限。
骨屑是一种自体骨的免费来源，在手术过程中可轻松采集，并用作促进骨融合的补充材料。需要进一步研究来评估骨屑的骨诱导潜力。骨屑中保留的生长因子可能会诱导局部骨祖细胞增殖并矿化形成新骨。
