伴有软骨样分化的化生性乳腺癌：一名38岁女性浸润性癌的罕见变体。
Metaplastic breast carcinoma with chondroid differentiation: a rare variant of infiltrative carcinoma in a 38-year-old woman.
作者信息
Taghipour Zahir Shokouh, Javannejad Mostafa
机构信息
Department of Pathology, Shahid Sadoughi University of Medical Sciences, Mortaz General Hospital, Yazd, Iran.
Department of Pathology, Mortaz General Hospital, Yazd, Iran.
出版信息
BMJ Case Rep. 2017 Jun 15;2017:bcr-2016-217687. doi: 10.1136/bcr-2016-217687.
Metaplastic breast carcinoma (MBC) is a rare type of invasive breast carcinoma, and chondroid differentiation is even rarer. Here we report a case of MBC with extensive chondroid differentiation in a 38-year-old woman who presented with a lump in her left breast. Ultrasound findings were most compatible with those of giant fibroadenoma. A histopathological examination revealed a malignant lesion comprising neoplastic epithelial cells arranged in solid nests, with large areas of chondroid differentiation. Neoplastic chondroid cells exhibited a positive reaction for S-100, patchy positive reaction for pan-cytokeratin (AE1/AE3) and negative reaction for epithelial membrane antigen. Both carcinomatous and chondroid cells exhibited p53 overexpression. Sentinel lymph node biopsy revealed no tumorous involvement.
化生性乳腺癌（MBC）是一种罕见的浸润性乳腺癌，软骨样分化更为罕见。在此，我们报告一例38岁患有广泛性软骨样分化的MBC女性病例，该患者因左乳肿块就诊。超声检查结果与巨大纤维腺瘤最为相符。组织病理学检查显示为恶性病变，由排列成实性巢状的肿瘤上皮细胞组成，伴有大面积软骨样分化。肿瘤软骨样细胞S-100呈阳性反应，泛细胞角蛋白（AE1/AE3）呈局灶性阳性反应，上皮膜抗原呈阴性反应。癌性细胞和软骨样细胞均表现为p53过表达。前哨淋巴结活检未发现肿瘤累及。
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