Kanthan Gowri L, Hsiao Edward, Vu Dzung, Schembri Geoffrey Paul
Department of Nuclear Medicine, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Prince of Wales Hospital Clinical School, University of New South Wales, Sydney, New South Wales, Australia.
J Med Imaging Radiat Oncol. 2017 Dec;61(6):732-738. doi: 10.1111/1754-9485.12622. Epub 2017 Jun 17.
The aim of this study was to assess the frequency of PSMA-HBED uptake in coeliac and stellate ganglia in patients presenting for PSMA-HBED PET/CT scan.
Prostate-specific membrane antigen-HBED PET/CT scans of 100 consecutive patients were analysed. Coeliac and stellate ganglia were identified by their anatomical location. PSMA-HBED uptake in these ganglia was recorded as either present or absent. If present, the SUV value for each ganglion was measured and compared to SUV of mediastinal blood pool.
Of the 100 patients, 45 had PSMA-HBED uptake in the right coeliac ganglion and 81 had PSMA-HBED uptake in the left coeliac ganglion. The mean SUV for the right coeliac ganglion was 2.6 (range 1.2-4.0) and for the left, 2.7 (range 1.2-6.5). An SUV 1.5 times greater than that of mediastinal blood pool activity was found in 25 of right and 47 of left coeliac ganglia. Stellate ganglion uptake of PSMA-HBED was identified in 54 of right and 74 of left stellate ganglia. The mean SUV for the right and left stellate ganglia were 2.2 (range 1.6-3.6) and 2.4 (range 1.4-4.2) respectively. An SUV 1.5 times greater than that of mediastinal blood pool activity was found in 12 of right and 32 of left coeliac ganglia.
Uptake in coeliac and stellate ganglia is a frequent finding on PSMA-HBED PET/CT imaging. Often this uptake can be sufficiently high to cause potential diagnostic confusion. It is important to be aware of this physiologic uptake to avoid incorrect diagnosis of metastatic prostate carcinoma.
本研究的目的是评估接受PSMA-HBED PET/CT扫描的患者腹腔神经节和星状神经节中PSMA-HBED摄取的频率。
对100例连续患者的前列腺特异性膜抗原-HBED PET/CT扫描进行分析。通过解剖位置识别腹腔神经节和星状神经节。记录这些神经节中PSMA-HBED的摄取情况，分为有或无。如果有摄取，则测量每个神经节的SUV值，并与纵隔血池的SUV进行比较。
100例患者中，45例右侧腹腔神经节有PSMA-HBED摄取，81例左侧腹腔神经节有PSMA-HBED摄取。右侧腹腔神经节的平均SUV为2.6（范围1.2 - 4.0），左侧为2.7（范围1.2 - 6.5）。右侧25个和左侧47个腹腔神经节的SUV比纵隔血池活性高1.5倍。右侧54个和左侧74个星状神经节发现有PSMA-HBED摄取。右侧和左侧星状神经节的平均SUV分别为2.2（范围1.6 - 3.6）和2.4（范围1.4 - 4.2）。右侧12个和左侧32个腹腔神经节的SUV比纵隔血池活性高1.5倍。
腹腔神经节和星状神经节摄取在PSMA-HBED PET/CT成像中很常见。这种摄取通常可能足够高，导致潜在的诊断混淆。意识到这种生理性摄取以避免对转移性前列腺癌的错误诊断很重要。
