School of Nursing & Midwifery, University of Southern Queensland, Toowoomba, Australia.
Institute of Resilient Regions, University of Southern Queensland, Toowoomba, QLD, 4370, Australia.
Syst Rev. 2017 Jun 17;6(1):115. doi: 10.1186/s13643-017-0515-6.
Metabolic syndrome (MetS) is defined by an accumulation of risk factors that include cardiovascular disease, diabetes, chronic high blood pressure, obesity, and hypercholesterolaemia which results in an increased risk of developing serious chronic diseases. MetS is widespread as it is estimated to affect up to 30% of the global population. For people with MetS who undergo surgery, an emerging body of literature points to significantly poorer postoperative outcomes compared with non-affected populations. Surgical patients with MetS are at significantly higher risk of a range of adverse outcomes including death, morbid cardiovascular events, coma, stroke, renal failure, myocardial infarction, and surgical site infections. Increased complication rates result in prolonged hospital stays, a greater need for post-hospitalisation care, and reduced effectiveness of surgical interventions.
METHODS/DESIGN: We will search the following electronic bibliographic databases: MEDLINE, EMBASE, ScienceDirect, and CINAHL, and the reference lists of included articles. We will also search for unpublished literature. Two authors will screen titles and abstract information independently and select studies according to established inclusion and exclusion criteria. Data will be extracted by the study investigators using Review Manager 5 and will include information on demographics, incidence, prevalence, and outcome variables. Subgroup analysis and sensitivity analysis will be performed to assess the heterogeneity of included studies. Meta-analysis will also be carried out if appropriate study groups are identified. A descriptive narrative for statistical data will also be provided to highlight findings of the systematic review and meta-analysis.
This study will report and summarise adverse outcomes among adult patients with MetS undergoing surgery across a range of surgical specialties. Developing insights into outcomes of this population of interest is necessary to develop guidelines towards better management of surgical patients with metabolic syndrome.
PROSPERO CRD42016051071.
代谢综合征（MetS）是由一系列心血管疾病、糖尿病、慢性高血压、肥胖和高胆固醇等危险因素积累而成的，这会增加罹患严重慢性疾病的风险。代谢综合征的发病率很高，据估计，全球有多达 30%的人口受到影响。对于接受手术的代谢综合征患者，与未受影响的人群相比，术后结果明显较差。患有代谢综合征的手术患者面临一系列不良后果的风险显著增加，包括死亡、严重心血管事件、昏迷、中风、肾衰竭、心肌梗死和手术部位感染。并发症发生率的增加导致住院时间延长、对出院后护理的需求增加以及手术干预效果降低。
方法/设计：我们将搜索以下电子文献数据库：MEDLINE、EMBASE、ScienceDirect 和 CINAHL，并搜索纳入文章的参考文献列表。我们还将搜索未发表的文献。两名作者将独立筛选标题和摘要信息，并根据既定的纳入和排除标准选择研究。研究人员将使用 Review Manager 5 提取数据，并包括人口统计学、发病率、患病率和结局变量信息。将进行亚组分析和敏感性分析，以评估纳入研究的异质性。如果确定了适当的研究组，将进行荟萃分析。还将提供对统计数据的描述性叙述，以突出系统评价和荟萃分析的发现。
本研究将报告和总结各种外科专业接受手术的代谢综合征成年患者的不良结局。了解这一感兴趣人群的结局对于制定更好地管理代谢综合征手术患者的指南是必要的。
PROSPERO CRD42016051071。
