妇科癌症女性更年期症状的管理。
Management of menopausal symptoms in women with gynecologic cancers.
作者信息
Del Carmen Marcela G, Rice Laurel W
机构信息
Division of Gynecologic Oncology, Vincent Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Department of Obstetrics and Gynecology, University of Wisconsin Hospital and Clinics, Madison, WI, United States.
出版信息
Gynecol Oncol. 2017 Aug;146(2):427-435. doi: 10.1016/j.ygyno.2017.06.013. Epub 2017 Jun 16.
OBJECTIVE
Women with gynecologic malignancies will be cured or may become long-term survivors. Management of menopausal symptoms is important in addressing their quality of life. We review the benefit and safety of hormone therapy use in these patients.
METHODS
MEDLINE was searched for studies on menopause management published in English through December of 2016.
RESULTS
Available data suggest that short-term use of hormone therapy in gynecologic cancer patients who do not have an estrogen-dependent malignancy do not adversely impact oncologic outcome and results in improvement of menopausal vasomotor and genitourinary symptoms. Evidence regarding safety of hormone therapy use in women with estrogen-dependent gynecologic malignances is currently lacking.
CONCLUSIONS
Candidates for hormone therapy in gynecologic oncology include women with menopausal symptoms diagnosed with low-grade, early-stage endometrial cancer, cervical, vulvar and vaginal cancer, and ovarian cancer.
目的
患有妇科恶性肿瘤的女性有望治愈或成为长期幸存者。更年期症状的管理对于提高她们的生活质量至关重要。我们回顾了这些患者使用激素疗法的益处和安全性。
方法
检索MEDLINE数据库，查找截至2016年12月以英文发表的关于更年期管理的研究。
结果
现有数据表明，在没有雌激素依赖性恶性肿瘤的妇科癌症患者中短期使用激素疗法不会对肿瘤学结局产生不利影响，且能改善更年期血管舒缩症状和泌尿生殖系统症状。目前缺乏关于雌激素依赖性妇科恶性肿瘤患者使用激素疗法安全性的证据。
结论
妇科肿瘤学中激素疗法的适用人群包括患有更年期症状且被诊断为低级别、早期子宫内膜癌、宫颈癌、外阴癌、阴道癌和卵巢癌的女性。
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