STING在细菌感染中的新作用
The Emerging Roles of STING in Bacterial Infections.
作者信息
Marinho Fabio V, Benmerzoug Sulayman, Oliveira Sergio C, Ryffel Bernhard, Quesniaux V F J
机构信息
CNRS, UMR7355, Orleans, France; Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
出版信息
Trends Microbiol. 2017 Nov;25(11):906-918. doi: 10.1016/j.tim.2017.05.008. Epub 2017 Jun 15.
Abstract
The STING (Stimulator of Interferon Genes) protein connects microorganism cytosolic sensing with effector functions of the host cell by sensing directly cyclic dinucleotides (CDNs), originating from pathogens or from the host upon DNA recognition. Although STING activation favors effective immune responses against viral infections, its role during bacterial diseases is controversial, ranging from protective to detrimental effects for the host. In this review, we summarize important features of the STING activation pathway and recent highlights about the role of STING in bacterial infections by Chlamydia, Listeria, Francisella, Brucella, Shigella, Salmonella, Streptococcus, and Neisseria genera, with a special focus on mycobacteria.
摘要
干扰素基因刺激蛋白（STING）通过直接感知源自病原体或宿主DNA识别后产生的环二核苷酸（CDN），将微生物胞质传感与宿主细胞的效应功能联系起来。尽管STING激活有利于针对病毒感染产生有效的免疫反应，但其在细菌疾病中的作用存在争议，对宿主的影响从保护到有害不等。在本综述中，我们总结了STING激活途径的重要特征以及STING在衣原体、李斯特菌、弗朗西斯菌、布鲁氏菌、志贺氏菌、沙门氏菌、链球菌和奈瑟氏菌属细菌感染中作用的最新亮点，特别关注分枝杆菌。
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