Kihira Tameko, Okamoto Kazushi, Sakurai Iori, Arakawa Yuya, Wakayama Ikuro, Takamiya Koichi, Okumura Ryo, Iinuma Yuhto, Iwai Keiko, Kokubo Yasumasa, Yoshida Sohei
Department of Health Sciences, Kansai University of Health Sciences, Japan.
Department of Public Health, Aichi Prefectural University, Japan.
Intern Med. 2017;56(12):1497-1506. doi: 10.2169/internalmedicine.56.8038. Epub 2017 Jun 15.
Objective Lifestyle changes may play an important role in the incidence reduction and delay of onset age of amyotrophic lateral sclerosis (ALS) in the Koza/Kozagawa/Kushimoto (K) area. The aim of this study was to evaluate recent lifestyle changes in the K area and to investigate the relationships between lifestyle and oxidative stress among the residents. Methods We conducted a medical checkup for elderly residents in the K area and the control area and evaluated the urinary 8-OHdG levels, cognitive function test scores and metal contents in serum and scalp hair, coupled with a lifestyle questionnaire survey between 2010 and 2015. Results Recent lifestyle changes among the K residents, including a decrease in the Japanese pickle consumption, increase in fresh vegetable consumption and decrease in farm work, were evaluated in this study. Low consumption of Japanese pickles, high consumption of fresh vegetables, rare farm work and low levels of 8-OHdG/creatinine were all associated with high scores in the cognitive function tests. Frequent farm work and consumption of Japanese pickles was associated with high contents of transition metals, such as Mn, Al and V, in the scalp hair. Conclusion These lifestyle changes among residents in the K area may be associated with their oxidative stress.
目的 生活方式的改变可能在降低小田原/小田川/串本（K）地区肌萎缩侧索硬化症（ALS）的发病率及延迟发病年龄方面发挥重要作用。本研究旨在评估K地区近期的生活方式变化，并调查该地区居民生活方式与氧化应激之间的关系。方法 我们对K地区和对照地区的老年居民进行了体检，评估了尿8-羟基脱氧鸟苷（8-OHdG）水平、认知功能测试得分以及血清和头皮头发中的金属含量，并在2010年至2015年期间进行了生活方式问卷调查。结果 本研究评估了K地区居民近期的生活方式变化，包括日本腌菜消费量的减少、新鲜蔬菜消费量的增加以及农活的减少。日本腌菜消费量低、新鲜蔬菜消费量高、农活少以及8-OHdG/肌酐水平低均与认知功能测试中的高分相关。频繁从事农活和食用日本腌菜与头皮头发中过渡金属（如锰、铝和钒）的高含量相关。结论 K地区居民的这些生活方式变化可能与他们的氧化应激有关。
