Kihira Tameko, Yoshida Sohei, Kondo Tetsuya, Iwai Keiko, Wada Sachiko, Morinaga Satomi, Kazimoto Yoshinori, Kondo Tomoyoshi, Okamoto Kazusi, Kokubo Yasumasa, Kuzuhara Shigeki
Department of Health Sciences, Kansai University of Health Sciences, Kumatori-cho, Sennan-gun, Osaka, Japan.
Amyotroph Lateral Scler. 2012 Jun;13(4):347-50. doi: 10.3109/17482968.2012.674140.
We investigated changes in the incidence of amyotrophic lateral sclerosis (ALS) in the Koza/Kozagawa/Kushimoto area (K. area) in the Kii Peninsula, Japan in 1960-2009. Probable and definite ALS cases diagnosed using El Escorial criteria were collected during a five-decade period: period I-V, 1960-2009. Forty-three ALS patients matched the selection criteria in the overall K. area, including three patients on Oshima, a small island opposite the mainland K. area. The age- and gender-adjusted incidence of ALS in the overall K. area (standardized for the 2005 Japanese population) decreased from 5.47/100,000 (95% CI 1.86-9.08) in period I to 0.61/100,000 (95% CI-0.28-1.50) in period III, and then increased to 4.39/100,000 (95% CI 1.70-7.07) in period V. On Oshima, the age- and gender-adjusted incidence of ALS was 9.45/100,000 (95% CI-7.39-26.29) in period V. The present research indicates an increase of ALS incidence in the K. area, especially on Oshima. A limitation of this study was the small population.
我们调查了1960年至2009年期间日本纪伊半岛小里/小川/串本地区（K地区）肌萎缩侧索硬化症（ALS）的发病率变化。在五十年期间收集了使用埃尔埃斯科里亚尔标准诊断的可能和确诊的ALS病例：1960年至2009年的第一至五期。在整个K地区，43例ALS患者符合选择标准，其中包括对马岛（与K地区大陆相对的一个小岛）上的3例患者。整个K地区（以2005年日本人口为标准）经年龄和性别调整后的ALS发病率从第一期的5.47/10万（95%可信区间1.86 - 9.08）降至第三期的0.61/10万（95%可信区间 - 0.28 - 1.50），然后在第五期升至4.39/10万（95%可信区间1.70 - 7.07）。在对马岛，第五期经年龄和性别调整后的ALS发病率为9.45/10万（95%可信区间 - 7.39 - 26.29）。本研究表明K地区，尤其是对马岛的ALS发病率有所上升。本研究的一个局限性是人口较少。
