Kitagawa Haruaki, Takeda Kahoru, Tsuboi Ririko, Hayashi Mikako, Sasaki Jun-Ichi, Imazato Satoshi
Department of Biomaterials Science, Osaka University Graduate School of Dentistry.
Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry.
Dent Mater J. 2017 Nov 29;36(6):724-730. doi: 10.4012/dmj.2016-372. Epub 2017 Jun 15.
Dental adhesive resins based on 4-methacryloxyethyl trimellitate anhydride (4-META)/methyl methacrylate (MMA) have been utilized for root-end filling and the bonding of fractured roots. To increase the success rate of these treatments, it would be beneficial to promote the healing of surrounding tissue by applying growth factors. In this study, the influences of the polymerization properties of 4-META/MMA-based resins on the activity of fibroblast growth factor-2 (FGF-2) were evaluated in vitro. The temperature increase caused by the heat generation during polymerization of the 4-META/MMA-based resin was insufficient to change the structure and function of FGF-2. Unpolymerized monomers released from the cured 4-META/MMA-based resin had no negative influences on the ability of FGF-2 to promote the proliferation of osteoblast-like cells. These findings suggest that it is possible to use FGF-2 in combination with 4-META/MMA-based resins.
基于偏苯三酸酐甲基丙烯酸羟乙酯（4-META）/甲基丙烯酸甲酯（MMA）的牙科粘结树脂已被用于根尖充填和折断牙根的粘结。为提高这些治疗的成功率，通过应用生长因子促进周围组织愈合将是有益的。在本研究中，体外评估了4-META/MMA基树脂的聚合性能对成纤维细胞生长因子-2（FGF-2）活性的影响。4-META/MMA基树脂聚合过程中产生的热量引起的温度升高不足以改变FGF-2的结构和功能。固化的4-META/MMA基树脂释放的未聚合单体对FGF-2促进成骨样细胞增殖的能力没有负面影响。这些发现表明，FGF-2与4-META/MMA基树脂联合使用是可能的。
