视神经脊髓炎谱系障碍合并31型脊髓小脑共济失调
Neuromyelitis Optica Spectrum Disorder Coinciding with Spinocerebellar Ataxia Type 31.
作者信息
Takahashi Yoshiaki, Manabe Yasuhiro, Morihara Ryuta, Narai Hisashi, Yamashita Toru, Abe Koji
机构信息
Department of Neurology, National Hospital Organization Okayama Medical Center, Okayama, Japan.
Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
出版信息
Case Rep Neurol. 2017 May 17;9(2):127-130. doi: 10.1159/000475657. eCollection 2017 May-Aug.
We report the unusual case of a 63-year-old man with spinocerebellar ataxia (SCA) type 31 who developed neuromyelitis optica spectrum disorder (NMOSD) 14 years after the onset of cerebellar symptoms. In addition to cerebellar atrophy, magnetic resonance imaging showed multiple high-intensity areas in the brain and a long thoracic cord lesion from Th1/2 to Th11. The combination of NMOSD and SCA31 is accidental. However, our case suggests that inflammatory processes could be involved in the pathogenesis of NMOSD and SCA31.
我们报告了一例罕见病例，一名63岁患有31型脊髓小脑共济失调（SCA）的男性，在出现小脑症状14年后发生了视神经脊髓炎谱系障碍（NMOSD）。除小脑萎缩外，磁共振成像显示脑部有多个高强度区域以及从胸1/2至胸11的长节段胸段脊髓病变。NMOSD和SCA31的合并情况较为偶然。然而，我们的病例提示炎症过程可能参与了NMOSD和SCA31的发病机制。
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