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多象限球结膜下注射曲安奈德治疗急性角膜移植排斥反应：一例报告

Multiquadrant Subtenon Triamcinolone Injection for Acute Corneal Graft Rejection: A Case Report.

作者信息

Goyal Sunali, Uwaydat Sami H

机构信息

Department of Ophthalmology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

出版信息

Case Rep Ophthalmol. 2017 May 29;8(2):308-313. doi: 10.1159/000477202. eCollection 2017 May-Aug.

DOI:10.1159/000477202
PMID:28626416
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5471750/
Abstract

BACKGROUND

We report a case of reversal of an acute corneal graft rejection following multiquadrant subtenon triamcinolone injection.

CASE PRESENTATION

A 19-year-old woman who had acute corneal graft rejection failed to show resolution of the graft rejection after standard treatment with systemic, intravenous, and topical steroids. The graft rejection, however, responded to injection of triamcinolone in multiple subtenon quadrants.

CONCLUSIONS

For corneal graft rejection, multiquadrant subtenon triamcinolone injections may be a safe adjunct to systemic treatment.

摘要

背景

我们报告了一例在多象限球结膜下注射曲安奈德后急性角膜移植排斥反应逆转的病例。

病例介绍

一名19岁女性发生急性角膜移植排斥反应，在接受全身、静脉和局部类固醇标准治疗后，移植排斥反应未得到缓解。然而，多象限球结膜下注射曲安奈德后，移植排斥反应得到了改善。

结论

对于角膜移植排斥反应，多象限球结膜下注射曲安奈德可能是全身治疗的一种安全辅助方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba68/5471750/3b46e8351f14/cop-0008-0308-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba68/5471750/a24d5ab4eda6/cop-0008-0308-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba68/5471750/7645e9c96e3a/cop-0008-0308-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba68/5471750/3b46e8351f14/cop-0008-0308-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba68/5471750/a24d5ab4eda6/cop-0008-0308-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba68/5471750/7645e9c96e3a/cop-0008-0308-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba68/5471750/3b46e8351f14/cop-0008-0308-g03.jpg

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本文引用的文献

1
Corneal Allograft Rejection: Immunopathogenesis to Therapeutics.角膜同种异体移植排斥反应：从免疫发病机制到治疗方法
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Characterisation of systemic and ocular drug level of triamcinolone acetonide following a single sub-Tenon injection.
经单次 Tenon 下注射后曲安奈德的全身和眼部药物水平的特征。
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Systemic absorption of triamcinolone acetonide after posterior sub-Tenon injection.后Tenon囊下注射曲安奈德后的全身吸收情况。
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Int Ophthalmol Clin. 2009 Winter;49(1):31-41. doi: 10.1097/IIO.0b013e3181924e23.
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Case-control study of subconjunctival triamcinolone acetonide injection vs intravenous methylprednisolone pulse in the treatment of endothelial corneal allograft rejection.结膜下曲安奈德醋酸酯注射与静脉注射甲基强的松龙脉冲治疗内皮性角膜同种异体移植排斥的病例对照研究。
Eye (Lond). 2009 Mar;23(3):708-14. doi: 10.1038/eye.2008.289. Epub 2008 Sep 26.
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Corneal graft rejection.角膜移植排斥反应。
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Twenty-five-year panorama of corneal immunology: emerging concepts in the immunopathogenesis of microbial keratitis, peripheral ulcerative keratitis, and corneal transplant rejection.角膜免疫学的25年全景：微生物性角膜炎、周边溃疡性角膜炎及角膜移植排斥反应免疫发病机制中的新观念
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Clinical types of corneal transplant rejection. Their manifestations, frequency, preoperative correlates, and treatment.角膜移植排斥反应的临床类型。其表现、发生率、术前相关因素及治疗。
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