Pimienta Michael, Edderkaoui Mouad, Wang Ruoxiang, Pandol Stephen
University of California, San Diego School of MedicineLa Jolla, CA, United States.
Cedars-Sinai Medical Center, Basic and Translational Pancreas ResearchLos Angeles, CA, United States.
Front Physiol. 2017 Jun 2;8:381. doi: 10.3389/fphys.2017.00381. eCollection 2017.
Pancreatic cancer is one the most lethal malignancies. Only a small proportion of patients with this disease benefit from surgery. Chemotherapy provides only a transient benefit. Though much effort has gone into finding new ways for early diagnosis and treatment, average patient survival has only been improved in the order of months. Circulating tumor cells (CTCs) are shed from primary tumors, including pre-malignant phases. These cells possess information about the genomic characteristics of their tumor source , and their detection and characterization holds potential in early cancer diagnosis, prognosis, and treatment. Liquid Biopsies present an alternative to tumor biopsy that are hard to sample. Below we summarize current methods of CTC detection, the current literature on CTCs in pancreatic cancer, and future perspectives.
胰腺癌是最致命的恶性肿瘤之一。只有一小部分患有这种疾病的患者能从手术中获益。化疗仅能提供短暂的益处。尽管人们付出了很多努力来寻找早期诊断和治疗的新方法，但患者的平均生存期仅延长了几个月左右。循环肿瘤细胞（CTC）从原发性肿瘤（包括癌前阶段）脱落。这些细胞携带来自其肿瘤来源的基因组特征信息，对它们的检测和表征在早期癌症诊断、预后和治疗方面具有潜力。液体活检为难以取样的肿瘤活检提供了一种替代方法。以下我们总结了目前CTC检测的方法、关于胰腺癌中CTC的当前文献以及未来展望。
