Dawson R, Valdes J J, Annau Z
Pharmacology. 1985;31(1):17-23. doi: 10.1159/000138093.
The arcuate nucleus (AN) is the presumed origin of the dopaminergic innervation of posterior lobe of the pituitary. Posterior lobe dopamine levels were determined in rats that had been neonatally treated with monosodium glutamate (MSG) to lesion the AN. MSG-induced AN damage was confirmed neurochemically, histologically and immunocytochemically. MSG treatment resulted in a substantial loss of AN neurons and approximately a 50% loss of dopamine uptake capacity (Vmax) in the mediobasal hypothalamus. Posterior pituitary dopamine levels were not significantly altered by MSG-induced AN damage. These results suggest that MSG treatment spares the tuberohypophyseal dopamine system and that the AN may not be the sole origin of the dopaminergic innervation of the posterior pituitary.
弓状核（AN）被认为是垂体后叶多巴胺能神经支配的起源部位。在新生期用谷氨酸单钠（MSG）处理以损伤弓状核的大鼠中测定了垂体后叶多巴胺水平。通过神经化学、组织学和免疫细胞化学方法证实了MSG诱导的弓状核损伤。MSG处理导致弓状核神经元大量丧失，且中基底下丘脑的多巴胺摄取能力（Vmax）大约丧失50%。MSG诱导的弓状核损伤并未使垂体后叶多巴胺水平发生显著改变。这些结果表明，MSG处理使结节垂体多巴胺系统得以保留，并且弓状核可能不是垂体后叶多巴胺能神经支配的唯一起源。
